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The role of protein kinase C and the glycoprotein Ibα cytoplasmic tail in anti-glycoprotein Ibα antibody-induced platelet apoptosis and thrombocytopenia.
Thromb Res
December 2024
Jiangsu Institute of Hematology, Cyrus Tang Medical Institute, The First Affiliated Hospital Collaborative Innovation Center of Hematology, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, National Clinical Research Center for Hematological Diseases, Suzhou, China. Electronic address:
Article Synopsis
- Immune thrombocytopenia (ITP) is an autoimmune condition where patients have low platelet counts, especially those with anti-GPIbα autoantibodies that resist standard treatments.
- PKC activation is triggered by von Willebrand factor binding to GPIbα, leading to platelet activation, but its role in antibody-induced thrombocytopenia is unclear.
- The study reveals that PKC activation involves GPIbα clustering and PI3K activation, leading to platelet apoptosis, and suggests that targeting PKC could be a new treatment strategy for ITP.
Management of anti-melanoma differentiation-associated gene 5 antibody-induced refractory dermatomyositis complicated by interstitial pneumonia using tofacitinib and its outcomes: a case report.
J Med Case Rep
September 2024
Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, minami1-nishi16Chuo-Ku, Sapporo, Hokkaido, 060-8543, Japan.
Article Synopsis
- Clinical amyopathic dermatomyositis is a skin condition that lacks muscle symptoms and is often associated with anti-melanoma differentiation-associated gene 5 antibodies, particularly in Japanese patients, leading to poor outcomes in those with lung complications.
- A 52-year-old male presented with severe respiratory issues and skin rashes, diagnosed with dermatomyositis-related interstitial pneumonia, but treatment with steroids and immunosuppressants was largely ineffective.
- Despite some initial improvement after switching medications, the patient ultimately faced worsening respiratory failure due to invasive pulmonary aspergillosis, resulting in a fatal outcome.
Chaihu Guizhi Decoction prevents cognitive, memory impairments and sensorimotor gating deficit induced by N-methyl-d-aspartate receptor antibody in mice.
J Ethnopharmacol
January 2025
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address:
Ethnopharmacological Relevance: Anti-NMDAR encephalitis is one of the most common types of autoimmune encephalitis, primarily presenting with prodromal symptoms, such as fever and headache, followed by a range of neurological and psychiatric symptoms. Chaihu Guizhi Decoction (CGD), a traditional Chinese medicine formulated by Zhang Zhongjing in the Eastern Han Dynasty, has been effectively used in clinical practice to treat the symptoms of Taiyang and Shaoyang disorders, including fever, headache, and psychiatric disorders.
Aim Of The Study: To demonstrate the protective effects of CGD in an animal model of anti-NMDAR encephalitis and explore the potential mechanisms involved.
Diagnostic value of antibody-induced procoagulant platelets in heparin-induced thrombocytopenia: communication from the ISTH SSC Subcommittee on Platelet Immunology.
J Thromb Haemost
March 2024
Institute for Clinical and Experimental Transfusion Medicine, Medical Faculty of Tübingen, University of Tübingen, Tübingen, Germany; Centre for Clinical Transfusion Medicine, Tübingen, Germany. Electronic address:
Article Synopsis
- - Heparin-induced thrombocytopenia (HIT) is an immune-related condition that leads to a decrease in platelet count and raises the risk of blood clots.
- - Diagnosing HIT requires both clinical evaluation and specific lab tests that identify the functional activities related to the disorder.
- - Experts emphasize the use of flow cytometry for diagnosing HIT and suggest that standardized protocols are essential for consistent and accurate results in clinical labs.
Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer.
Int J Mol Sci
October 2023
European Commission, Joint Research Centre (JRC), 21027 Ispra, Italy.
Analytical ultracentrifugation (AUC) analysis shows that the SARS-CoV-2 trimeric Spike (S) protein adopts different quaternary conformations in solution. The relative abundance of the "open" and "close" conformations is temperature-dependent, and samples with different storage temperature history have different open/close distributions. Neutralizing antibodies (NAbs) targeting the S receptor binding domain (RBD) do not alter the conformer populations; by contrast, a NAb targeting a cryptic conformational epitope skews the Spike trimer toward an open conformation.
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