Objective: To assess the feasibility of adding letrozole to the standard regimen of mifepristone and misoprostol for termination of pregnancy up to 63 days.
Study Design: We recruited 50 subjects who had requested legal termination of pregnancy up to 63 days. Medical abortion was performed with a singe dose of 200 mg mifepristone and 10 mg of letrozole daily for 3 days followed by 800 mcg vaginal misoprostol.
Results: The complete abortion rate was 98% (95% CI: 94-100%). The median induction-to-abortion interval of the regimen was 5.1 h (range 1.2-56 h). No serious adverse effects were reported.
Conclusions: The results of this pilot study suggest that a regimen of mifepristone, letrozole and misoprostol is associated with a high complete abortion rate without major adverse events.
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