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Reconstruction of Back Defect from Giant Congenital Melanocytic Nevus Using Dermal Substitute Matrix.
Plast Reconstr Surg Glob Open
January 2025
From the Division of Plastic and Reconstructive Surgery, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Giant congenital melanocytic nevi are large pigmented premalignant lesions present at birth that have an associated risk of malignant transformation. Full-thickness excision of these lesions would be required to eliminate this risk. However, giant nevi can leave behind large defects that can be challenging to reconstruct.
View Article and Find Full Text PDFAntioxidant and Anti-Inflammatory Impacts of Soft Tissue Crude Extract and Mucous of Snail Helix aspersa on an Excision Wound Model in Mice.
J Exp Zool A Ecol Integr Physiol
January 2025
Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.
Wound healing is a complex natural process in which tissue requires recovering injured tissue cells. Helix aspersa has a high nutritional value and is considered a rich natural source of antioxidants and anti-inflammatory agents. So, this study aimed to assess the effect of soft tissue crude extract and mucous of H.
View Article and Find Full Text PDFSuccessful engraftment of skin grafts highly depends on the quality of the wound bed. Good quality of blood vessels near the surface is critical to support the viability of the graft. Ischemic, irradiated scar tissue, bone and tendons will not have the sufficient blood supply.
View Article and Find Full Text PDFEnhanced Wound Healing and Autogenesis Through Lentiviral Transfection of Adipose-Derived Stem Cells Combined with Dermal Substitute.
Biomedicines
December 2024
Department of Plastic Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China.
Background: Burns and chronic ulcers may cause severe skin loss, leading to critical health issues like shock, infection, sepsis, and multiple organ failure. Effective healing of full-thickness wounds may be challenging, with traditional methods facing limitations due to tissue shortage, infection, and lack of structural support.
Methods: This study explored the combined use of gene transfection and dermal substitutes to improve wound healing.
Hyaluronic acid-based dermal substitute with stromal vascular fraction vs. partial thickness skin grafts for the treatment of intermediate-deep burns of the hand: a retrospective case-control study.
Ann Burns Fire Disasters
December 2024
Division of Plastic and Reconstructive Surgery, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy.
Deep intermediate burns of the hand are a challenge for both the functional and aesthetic result. In this study we compare the efficacy of early selective enzymatic escarolysis followed by the application of stromal vascular fraction (SVF) extracted from autologous adipose tissue on a dermal substitute scaffold (DS) versus reconstruction by partial thickness skin grafts (PTSG). We enrolled all patients admitted to our referral Burn Center from September 2020 to January 2022 with deep intermediate burns of the hands: clinical data were collected, then the first group of 4 patients were treated with PTSG surgical reconstruction, and the second group of 7 patients with DS+SVF.
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