Purpose: Lung development and consequently, lung volumes, are affected by the duration, type and intensity of sporting. Athletes may have higher spirometric values compared to predicted which may lead to misclassification of this population and misdiagnosis during clinical evaluation. The aim of the study was to compare measured spirometric values with those predicted from the European Community for Steel and Coal statement in Greek professional athletes.
Methods: Measured and predicted spirometric values were recorded from 276 normal professional athletes (168 males, 108 females), aged 15-60 years originated from the metropolitan area of Athens, Greece. Predicted and measured spirometric values were compared using a paired sample t-test and analysed using Bland-Altman method.
Results: Measured FEV1 was 109.6 (1.02%) and 109.4 (1.29%) and FVC was 110.8 (1.07%) and 109.6 (1.02%) compared to predicted in males and females respectively. The FEV1 /FVC ratio was 102.2 (0.55%) and 103.2 (0.58%) compared to predicted for males and females, respectively. Bland-Altman analysis revealed a significant bias and magnitude of difference between predicted and measured spirometric values.
Conclusions: European Community for Steel and Coal predicted spirometric values significantly underestimated measured lung volumes and FEV1 /FVC ratio in Greek athletes of both sexes. Predicted spirometric indices should be used with caution in the evaluation of athletes presenting with respiratory symptoms for the risk of underestimation of restrictive disease or airway obstruction.
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http://dx.doi.org/10.1111/crj.12066 | DOI Listing |
Respir Med
January 2025
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Clalit Health Services, Dan Petah Tikva District, Petah Tikva, Israel. Electronic address:
Background: Morbid obesity in adolescents impacts respiratory function, often leading to reduced lung volume and obstructive ventilatory defects. However, standard spirometric values frequently remain within normal ranges.
Objectives: We hypothesized that Lung Clearance Index (LCI) is a more sensitive marker for detecting airway dysfunction in adolescents with morbid obesity than conventional lung function tests.
J Asthma
January 2025
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Objective: It is well-known that children who suffer from obesity and asthma may also have exercise-induced bronchospasm. Exhaled nitric oxide is an indicator of airway inflammation, and could be affected by exercise. This study looked at how exercise, which is a typical cause of acute airway obstruction, affects the levels of FeNO and spirometric parameters in obese and asthmatic children.
View Article and Find Full Text PDFmedRxiv
January 2025
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Though European Respiratory Society and American Thoracic Society (ERS/ATS) guidelines for pulmonary function test (PFT) interpretation recommend the use of the forced vital capacity (FVC) lower limit of normal (LLN) to exclude restriction, recent data suggest that the negative predictive value (NPV) of the FVC LLN is lower than has been accepted, particularly among non-Hispanic Black patients. We sought to develop and externally validate a machine learning (ML) model to predict restriction from spirometry and determine whether its use may improve the accuracy and equity of PFT interpretation.
Methods: We included PFTs with both static and dynamic lung volume measurements for patients between 18 and 80 years of age who were tested at pulmonary diagnostic labs within two health systems.
J Clin Med
December 2024
Department for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
: Cough variant asthma (CVA) is characterized by nonspecific symptoms and normal spirometric values, which makes diagnosis challenging. To diagnose CVA it is necessary to document airway hyperreactivity (AHR). The aim of our study was to evaluate the diagnostic value of body plethysmography in the assessment of AHR using the methacholine challenge test (MCT).
View Article and Find Full Text PDFLung
January 2025
National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Purpose: This study examined the concavity (angle β, central and peripheral concavity) of the descending limb of the maximal expiratory flow-volume (MEFV) curves to reflect various ventilatory defects, including obstructive, restrictive, or mixed patterns.
Methods: We conducted a cross-sectional study collecting spirometry data from a healthcare center and a tertiary hospital between 2017 and 2022, with additional raw flow-volume curve data from primary healthcare institutions in 2023. We analyzed differences in concavity between spirometric patterns.
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