Effect of pegylated hyaluronate-endo-β-N-acetylhexosaminidase on humoral mechanisms regulating the functions of progenitor cells during chronic hepatitis.

A M Dygai G N Zyuz'kov R V Gurto V V Zhdanov E V Udut L A Miroshnichenko E V Simanina L A Stavrova A V Chaikovskiy T S Markova M Yu Minakova P G Madonov D N Kinsht A V Artamonov A A Bekarev

Bull Exp Biol Med

Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management Company, Novosibirsk, Russia.

Published: June 2013

We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced.

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http://dx.doi.org/10.1007/s10517-013-2106-4	DOI Listing

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