Prolactin actions.

J Mol Endocrinol

Program in Systems Biology and Physiology, Department of Molecular and Cellular Physiology James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45067-0476, USA.

Published: February 2014

Molecular genetics and other contemporary approaches have contributed to a better understanding of prolactin (PRL) actions at the cellular and organismal levels. In this review, several advances in knowledge of PRL actions are highlighted. Special emphasis is paid to areas of progress with consequences for understanding of human PRL actions. The impacts of these advances on future research priorities are analyzed.

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-13-0220DOI Listing

Publication Analysis

Top Keywords

prl actions
12
prolactin actions
4
actions molecular
4
molecular genetics
4
genetics contemporary
4
contemporary approaches
4
approaches contributed
4
contributed better
4
better understanding
4
understanding prolactin
4

Similar Publications

Cognitive processes such as action planning and decision-making require the integration of multiple sensory modalities in response to temporal cues, yet the underlying mechanism is not fully understood. Sleep has a crucial role for memory consolidation and promoting cognitive flexibility. Our aim is to identify the role of sleep in integrating different modalities to enhance cognitive flexibility and temporal task execution while identifying the specific brain regions that mediate this process.

View Article and Find Full Text PDF

The embryonic diapause of the giant panda (Ailuropoda melanoleuca) has caused great difficulties in monitoring pregnancy in this vulnerable species. The secretion of prolactin (PRL) from anterior pituitary glandular lactotropic cells is an important signal for the termination of embryonic dormancy. Currently, the mechanism by which PRL affects embryonic diapause in giant pandas and methods for detecting PRL in this species are poorly understood.

View Article and Find Full Text PDF

Prolactin locally mediates follicular atresia in hyperprolactinemic vizcachas (Rodentia, Chinchillidae).

Comp Biochem Physiol A Mol Integr Physiol

February 2025

Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD) Universidad Maimónides, Hidalgo 775, C1405BCK Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address:

Infertility in hyperprolactinemic females is attributed to the dysregulation of GnRH release, subsequently affecting gonadotropin levels, and ultimately leading to anovulation. However, in addition to the hypothalamus, prolactin receptor (PRLR) is expressed in ovaries as well, suggesting potential local effects of PRL in cases of hyperprolactinemia. We have developed an experimental model of sulpiride (SPD)-induced hyperprolactinemia using a wild rodent, the plains vizcacha, and studied the implications of pharmacological PRL levels on folliculogenesis and steroid production.

View Article and Find Full Text PDF

Modern approach to bone comorbidity in prolactinoma.

Pituitary

December 2024

Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS Hospital, Via Olgettina 60, Milan, 20132, Italy.

Prolactinomas account for more than half of pituitary adenomas, and besides their clinical impact on fertility and gonadal function, they lead to detrimental effects on bone. Patients with prolactinoma are prone to deterioration of bone structure caused not only by prolactin (PRL) induced hypogonadism but also by its direct actions on bone cells and calcium metabolism. However, clinical studies have shown inconsistent evidence regarding whether PRL could have a deleterious effect independently from gonadal insufficiency on skeletal integrity.

View Article and Find Full Text PDF

Comparison of different processed products of for the treatment of mice asthenozoospermia.

Transl Androl Urol

October 2024

Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, China.

Article Synopsis
  • GZP, a co-processed mixture with salt and wine, effectively treats asthenozoospermia (reduced sperm motility) in mice by enhancing sexual function and testicular health.
  • The study involved establishing a mouse model for the condition and testing six products, revealing GZP significantly improves sperm count, survival, and reduces deformities.
  • GZP appears to work by inhibiting excessive mitophagy and maintaining mitochondrial integrity, reducing harmful reactive oxygen species (ROS), and blocking certain protein expressions related to cell death.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!