Purpose: To assess the impact of weight loss on health-related quality-of-life (HRQL), to describe the factors associated with improvements in HRQL after weight loss, and to assess the relationship between obesity as assessed by body mass index (BMI) and HRQL before and after weight loss.
Methods: We studied 188 obese patients with BMI ≥ 32 kg/m(2) with one or more comorbidities or ≥35 kg/m(2). All patients had baseline and follow-up assessments of BMI and HRQL using the EuroQol (EQ-5D) and its visual analog scale (VAS) before and after 6 months of medical weight loss that employed very low-calorie diets, physical activity, and intensive behavioral counseling.
Results: At baseline, age was 50 ± 8 years (mean ± SD), BMI was 40. 0 ± 5.0 kg/m(2), EQ-5D-derived health utility score was 0.85 ± 0.13, and VAS-reported quality-of-life was 0.67 ± 0.18. At 6-month follow-up, BMI decreased by 7.0 ± 3.2 kg/m(2), EQ-5D increased by 0.06 [interquartile range (IQR) 0.06-0.17], and VAS increased by 0.14 (IQR 0.04-0.23). In multivariate analyses, improvement in EQ-5D and VAS were associated with lower baseline BMI, greater reduction in BMI at follow-up, fewer baseline comorbidities, and lower baseline HRQL. For any given BMI category, EQ-5D and VAS tended to be higher at follow-up than at baseline.
Conclusion: Measured improvements in HRQL between baseline and follow-up were greater than predicted by the reduction in BMI at follow-up. If investigators use cross-sectional data to estimate changes in HRQL as a function of BMI, they will underestimate the improvement in HRQL associated with weight loss and underestimate the cost-utility of interventions for obesity treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966959 | PMC |
| http://dx.doi.org/10.1007/s11136-013-0557-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Capromorelin on Appetite and Weight Gain of Domestic Pigeons ().
J Avian Med Surg
January 2025
Department of Small Animal Medicine and Surgery (Zoological Medicine), University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA,
Weight loss and decreased appetite are commonly encountered sequela of disease and stress in avian patients. However, there is currently minimal information in the veterinary literature regarding appetite stimulation in birds. Capromorelin is a potent agonist of the growth hormone secretagogue receptor and increases food consumption via direct stimulation of the hunger centers of the hypothalamus.
View Article and Find Full Text PDFCell-Cultured Influenza Vaccine Enhances IFN-γ+ T Cell and Memory T Cell Responses Following A/Victoria/2570/2019 IVR-215 (A/H1N1) Infection.
Vaccines (Basel)
December 2024
The Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Annex to Seoul Saint Mary Hospital, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Background: Influenza remains a significant public health challenge, with vaccination being a substantial way to prevent it. Cell-cultured influenza vaccines have emerged to improve on the drawbacks of egg-based vaccines, but there are few studies focusing on T cell immunity with both types of vaccines. Therefore, we studied the following 2022-2023 seasonal influenza vaccines with a standard dose and high dose: cell-based (C_sd and C_hd) and egg-based (E_sd and E_hd) vaccines.
View Article and Find Full Text PDFComputationally Optimized Hemagglutinin Proteins Adjuvanted with Infectimune Generate Broadly Protective Antibody Responses in Mice and Ferrets.
Vaccines (Basel)
December 2024
Center for Vaccines and Immunology, University of Georgia, Athens, GA 30605, USA.
Standard-of-care influenza vaccines contain antigens that are typically derived from components of wild type (WT) influenza viruses. Often, these antigens elicit strain-specific immune responses and are susceptible to mismatch in seasons where antigenic drift is prevalent. Thanks to advances in viral surveillance and sequencing, influenza vaccine antigens can now be optimized using computationally derived methodologies and algorithms to enhance their immunogenicity.
View Article and Find Full Text PDFAccurate Arrhythmia Classification with Multi-Branch, Multi-Head Attention Temporal Convolutional Networks.
Sensors (Basel)
December 2024
School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China.
Electrocardiogram (ECG) signals contain complex and diverse features, serving as a crucial basis for arrhythmia diagnosis. The subtle differences in characteristics among various types of arrhythmias, coupled with class imbalance issues in datasets, often hinder existing models from effectively capturing key information within these complex signals, leading to a bias towards normal classes. To address these challenges, this paper proposes a method for arrhythmia classification based on a multi-branch, multi-head attention temporal convolutional network (MB-MHA-TCN).
View Article and Find Full Text PDFEnhanced Intrusion Detection for ICS Using MS1DCNN and Transformer to Tackle Data Imbalance.
Sensors (Basel)
December 2024
School of Artificial Intelligence and Data Science, Hebei University of Technology, Tianjin 300132, China.
With the escalating threat posed by network intrusions, the development of efficient intrusion detection systems (IDSs) has become imperative. This study focuses on improving detection performance in programmable logic controller (PLC) network security while addressing challenges related to data imbalance and long-tail distributions. A dataset containing five types of attacks targeting programmable logic controllers (PLCs) in industrial control systems (ICS) was first constructed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!