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Development of nucleic acid-based vaccines against dengue and other mosquito-borne flaviviruses: the past, present, and future.
Front Immunol
January 2025
Infectious Disease Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University of Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Due to their widespread geographic distribution and frequent outbreaks, mosquito-borne flaviviruses, such as DENV (DENV), Zika virus (ZIKV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and West Nile virus (WNV), are considered significant global public health threats and contribute to dramatic socioeconomic imbalances worldwide. The global prevalence of these viruses is largely driven by extensive international travels and ecological disruptions that create favorable conditions for the breeding of and species, the mosquito vectors responsible for the spread of these pathogens. Currently, vaccines are available for only DENV, YFV, and JEV, but these face several challenges, including safety concerns, lengthy production processes, and logistical difficulties in distribution, especially in resource-limited regions, highlighting the urgent need for innovative vaccine approaches.
View Article and Find Full Text PDFSpatiotemporal morphodynamics of an ephemeral Himalayan River impacted by sand mining: A process-response framework.
Sci Total Environ
January 2025
Department of Earth Sciences, Indian Institute of Technology Kanpur, Kanpur 208016, India. Electronic address:
In-channel sediment mining significantly disrupts reach-scale sediment connectivity and channel geometry, causing immediate and intense geomorphological responses. River systems perturbed by anthropogenic stress, like sand and gravel mining, tend to respond within a shorter timescale, making the study of feedback mechanisms important. 'Sensitive' rivers display dramatic change via a positive feedback mechanism, exacerbating the change in the system.
View Article and Find Full Text PDFDramatic effect of extreme rainfall event and storm on microbial community dynamics in a subtropical coastal region.
Sci Total Environ
January 2025
Institute of Marine Environment and Ecology, National Taiwan Ocean University, Keelung 202-24, Taiwan; Doctoral Degree Program in Ocean Resource and Environmental Changes, National Taiwan Ocean University, Keelung 202-24, Taiwan; Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 202-24, Taiwan. Electronic address:
Extreme weather events, such as heavy rainfall and typhoons, are becoming more frequent due to climate change and can significantly impact coastal microbial communities. This study examines the short-term alterations in microbial food webs-viruses, bacteria, picophytoplankton, nanoflagellates, ciliates, and diatom-following Typhoon Krathon in Taiwan's coastal waters in October 2024. Daily in situ sampling revealed a significant post-typhoon increased in viral, nanoflagellate, and Synechococcus spp.
View Article and Find Full Text PDFImmunotherapy Responsive Recurrent Post-Infectious Ataxia Associated With Recurrent Gene Variant.
Neurol Genet
February 2025
Division of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, CA; and.
Objectives: We detail a case of recurrent, postinfectious, cerebellar ataxia associated with a likely pathogenic previously documented gene variant in .
Methods: The patient was identified after her second hospitalization for postinfectious cerebellar ataxia. Genetic testing was performed after discharge.
Recombinant Marek's disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus.
Front Microbiol
January 2025
Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken infectious anemia virus (CIAV), and it poses a serious threat to the poultry industry. However, effective control measures and strategies have not been identified. In this study, a recombinant Marek's disease virus (rMDV) expressing the VP1 and VP2 proteins of CIAV was successfully constructed using CRISPR/Cas9, and a commercial Marek's disease virus (MDV) vaccine strain was used as the vector.
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