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Increased Prevalence of Skeletal Anomalies on Ultrasound Evaluation of Buprenorphine-Exposed Human Fetuses.
South Med J
January 2025
Department of Obstetrics and Gynecology, East Tennessee State University, Johnson City.
Objectives: In this study, buprenorphine was the primary source of maternal opioid exposure at the time of initial prenatal evaluation. Current recommendations advise that level II ultrasounds be performed in patients with substance use disorders. For some patients, distance, transportation, and costs associated with obtaining ultrasounds from a specialist pose significant barriers.
View Article and Find Full Text PDFEffect of coenzyme Q10 on tibial fracture resistance in nicotine-exposed rats.
PLoS One
January 2025
Division of Periodontics, Department of Diagnosis and Surgery, UNESP, São Paulo State University "Júlio de Mesquita Filho", Araçatuba, Brazil.
The study aimed to evaluate the potential protection against fractures of oral Q10 supplementation in the tibias of rats exposed to nicotine. Nicotine is known to negatively impact bone density and increase the risk of fractures, in addition to affecting other systems such as the gastrointestinal system, impairing its absorption capacity, negatively affecting bone health. To investigate this, eighty male rats were divided into four groups (n = 20) receiving either nicotine hemisulfate or saline solution (SS) for 28 days.
View Article and Find Full Text PDFEffect of nanoparticulate CaCO on the biological properties of calcium silicate cement.
Sci Rep
January 2025
Department of Dental Biomaterials Science, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
This study aimed to evaluate the effects of nanoparticulate CaCO (NPCC) on the biological properties of calcium silicate-based cements (CSCs), including their cytotoxicity, in vitro osteogenic activity, and interactions with rat femur tissue. The average size of NPCC was 90.3±26.
View Article and Find Full Text PDFMANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression.
Sci Rep
January 2025
Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical University, No.137, Liyu Mountain South Road, Urumqi City, 830054, Xinjiang Province, China.
Intervertebral disc degeneration (IDD) is a degenerative condition associated with impaired mitophagy. MANF has been shown to promote mitophagy in murine kidneys; however, its role in IDD remains unexplored. This study aimed to elucidate the mechanism by which MANF influences IDD development through the regulation of mitophagy.
View Article and Find Full Text PDFTomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway.
Drug Des Devel Ther
January 2025
Department of Orthopaedics, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, People's Republic of China.
Article Synopsis
- Intervertebral disc degeneration (IDD) is a major cause of low back pain, and this study explores the potential of tomatidine (Td) as a treatment option by examining its effects on nucleus pulposus cells (NPCs) and a lumbar instability model.
- The results show that Td enhances the production of extracellular matrix (ECM), decreases its breakdown, and mitigates oxidative stress and ferroptosis in NPCs, which are crucial processes related to IDD.
- Td demonstrates a protective effect against IDD through the activation of the Nrf2/HO-1/GPX4 signaling pathway, indicating it could be a valuable therapeutic candidate for managing IDD.
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