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Light-Dependent Chemoselective Amide or Thioamide Ligation of Acylsilanes with Amines using Elemental Sulfur.
Chemistry
January 2025
Xi'an Jiaotong University, School of Chemistry, No.28, West Xianning Road, 710049, Xi'an, CHINA.
Due to the diverse chemical and physical properties of functional groups, mild and controllable ligation methods are often required to construct complex drugs and functional materials. To make diverse sets of products with tunable physicochemical properties, it is also useful to employ complimentary ligation methods that adopt the same starting materials. Here, we disclose the efficient and modular synthesis of amides or thioamides through the chemical ligation of acyl silanes with amines, simply by turning a light on or off.
View Article and Find Full Text PDFSkin-Integrated Electrogenetic Regulation of Vasculature for Accelerated Wound Healing.
Adv Sci (Weinh)
January 2025
ETH Zurich, Department of Biosystems Science and Engineering, Klingelbergstrasse 48, Basel, CH-4056, Switzerland.
Neo-vascularization plays a key role in achieving long-term viability of engineered cells contained in medical implants used in precision medicine. Moreover, strategies to promote neo-vascularization around medical implants may also be useful to promote the healing of deep wounds. In this context, a biocompatible, electroconductive borophene-poly(ε-caprolactone) (PCL) 3D platform is developed, which is called VOLT, to support designer cells engineered with a direct-current (DC) voltage-controlled gene circuit that drives secretion of vascular endothelial growth factor A (VEGFA).
View Article and Find Full Text PDFTraining and validating a treatment recommender with partial verification evidence.
Artif Intell Med
December 2024
Knowledge Management & Discovery Lab, Otto-von-Guericke-University Magdeburg, Germany. Electronic address:
Background: Current clinical decision support systems (DSS) are trained and validated on observational data from the clinic in which the DSS is going to be applied. This is problematic for treatments that have already been validated in a randomized clinical trial (RCT), but have not yet been introduced in any clinic. In this work, we report on a method for training and validating the DSS core before introduction to a clinic, using the RCT data themselves.
View Article and Find Full Text PDFScalable and Low-energy Synthesis of Metal-organic Frameworks by a Seed-mediated Approach.
Angew Chem Int Ed Engl
January 2025
USTC: University of Science and Technology of China, Department of Chemistry, No. 96 Jinzhai Road, 230026, Hefei, CHINA.
The synthesis of metal-organic frameworks (MOFs) by low energy input has been a long-term target for practical applications yet remains a great challenge. Herein, we developed a low-energy MOF growth strategy at a temperature down to 50 °C by simply introducing seeds into the reaction system. The MOFs are continuously grown on the surface of the seeds at a growth rate dozens of times higher than that of conventional solvothermal synthesis at low temperature, while the resulting MOFs possess high crystallinity, porosity, and stability similar to solvothermal seeds.
View Article and Find Full Text PDFFacile Fabrication of Monodisperse Vinyl Hybrid Core-Shell Silica Microsphere with Short Range Radial Channel in bi-phase System.
Small
January 2025
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
The development of monodisperse hybrid silica microspheres with highly regular pore structure and uniform distribution of functional groups have significant value in the biomolecular separation field. In this work, the short range ordered pore channels are precisely constructed onto the non-porous silica microsphere surface by a bi-phase assembly method, and the cylindrical silica channel introduced a plethora of vinyl groups by "one-pot" co-condensation to form vinyl hybrid silica shell. As hydrophilic interaction chromatography (HILIC) stationary phase, the vinyl hybrid core-shell silica microsphere is simply modified with zwitterion glutathione (SiO@SiO-GSH), in which the HILIC enrichment process is significantly shortened due to its specific porous characteristics.
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