[Effects of early goal-directed diuresis therapy on the outcomes of critical ill patients].

Zhonghua Yi Xue Za Zhi

Department of Surgical Intensive Care Unit, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Published: June 2013

AI Article Synopsis

  • The study aimed to assess the impact of early goal-directed diuresis therapy on critical ill patients' outcomes.
  • A total of 56 patients were treated with furosemide and split into two groups based on their central venous pressure (CVP) levels.
  • Results showed that the group achieving the lower CVP had a significantly higher survival rate and shorter ICU and ventilation days compared to the control group, indicating that early diuresis therapy can enhance patient prognosis.

Article Abstract

Objective: To evaluate the effects of early goal-directed diuresis therapy on the outcomes of critical ill patients.

Methods: A total of 56 critical patients enrolled received an injection of furosemide 5-40 mg under a precondition of stable hemodynamics. They were divided into two groups:standard group [Central venous pressure (CVP) decreased below 8 mm Hg] (n = 30) and control group (if not) (n = 26) depending on the goal of CVP.And the differences of survival rate, intensive care unit (ICU) days and ventilation days after diuresis therapy were compared between two groups.

Results: The survival rate of standard group was significantly higher than that of control group (96.7% vs 84.6%, P < 0.05) while the ICU days (4.4 ± 3.6 days) and ventilation days (1.2 ± 1.1 days) after diuresis therapy of standard group were significantly shorter than that of control group (12.5 ± 11.7 and 9.8 ± 9.6 days, P < 0.05).

Conclusion: Early goal-directed diuresis therapy can improve the prognosis of critical ill patients.

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