We report a 77-year-old man, presenting with progressive aphasia as an initial symptom, who developed severe dementia over the course of 20 months. Frontal cortex PrPSc western blot was type 2 and codon 129 was MM; brain neuropathology showed cortical vacuoles with perivacuolar PrP immunostaining characteristic of MM2C. Cerebellum showed focal coarse, patchy staining in different sections of the molecular layer, diffuse fine punctuate and coarse PrP immunopositive deposits in the granule cell layer, and focal synaptic immunostaining in the molecular layer, suggestive of MM1+2C by histotyping. This clinical presentation has not yet been described in an MM1+2C subtype by histotyping.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3233/JAD-130350 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vacuum electrospray deposition for face-on orientation and interface preservation in organic photovoltaics.
Sci Rep
January 2025
Department of Physics, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Despite recent advancements in organic photovoltaics (OPVs), further improvements in power conversion efficiency (PCE) and device lifetime are necessary for commercial viability. Strategies such as optimizing the molecular orientation and minimizing the charge traps of organic films are particularly effective in enhancing photovoltaic performance. In this study, we successfully utilized vacuum electrospray deposition (VESD) to achieve favourable face-on stacking geometries while preserving the integrity of the interfaces in poly(3-hexylthiophene-2,5-diyl) (P3HT): [6,6]-phenyl-C-butyric acid methyl ester (PCBM) bulk heterojunction (BHJ) films.
View Article and Find Full Text PDFButterfly pupal wing tissue with an eyespot organizer.
Cells Dev
January 2025
Tunicate Laboratory, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Okinawa, Japan.
Butterfly wing eyespots are developmentally determined at the early pupal stage, when prospective eyespot focal cells underneath the pupal cuticle focal spot function as eyespot organizers in the pupal wing tissue. Here, we performed light microscopy and transmission electron microscopy (TEM) to describe cellular structures of pupal wing tissue with an eyespot organizer immediately after pupation using the Blue Pansy butterfly Junonia orithya. The pupal forewing dorsal epidermis was a pseudostratified monolayer of vertically elongated epidermal cells.
View Article and Find Full Text PDFFormation of molecularly imprinted polymers: Strategies applied for the removal of protein template (review).
Adv Colloid Interface Sci
December 2024
Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University (VU), Naugarduko Str. 24, LT-03225 Vilnius, Lithuania; Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Saulėtekio Ave. 3, LT-10257 Vilnius, Lithuania. Electronic address:
The key step in the entire molecularly imprinted polymer (MIP) preparation process is the formation of the complementary cavities in the polymer matrix through the template removal process. The template is removed using chemical treatments, leaving behind selective binding sites for target molecules within the polymer matrix. Other MIP preparation steps include mixing monomers and template molecules in the appropriate solvent(s), monomer-template complex equilibration, and polymerisation of the monomers around the template.
View Article and Find Full Text PDFEnhancement of Spontaneous Orientation Polarization in Glassy Organic Semiconductor Mixtures.
J Phys Chem B
January 2025
Institut für Physik, Universität Augsburg, 86159 Augsburg, Germany.
The alignment of permanent dipole moments and the resulting spontaneous orientation polarization (SOP) are commonly observed in evaporated neat films of polar organic molecules and lead to a so-called giant surface potential. In the case of mixed films, often enhanced molecular orientation is observed, i.e.
View Article and Find Full Text PDFImpact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells.
Regen Med
January 2025
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Aims: Human periodontal ligament stem cells (hPDLSCs) exhibit an enormous potential to regenerate periodontal tissue. However, their translatability to the clinical setting is constrained by technical difficulties in standardizing culture conditions. The aim was to assess complex culture conditions using a proteomic-based protocol to standardize multi-layer hPDLSC cultivation methodology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!