AI Article Synopsis
- - Researchers found mutations in the STAG2 gene in 36% of non-invasive and 16% of invasive bladder cancers, indicating its significance in the disease.
- - STAG2 is important for regulating how chromosomes are organized and separated during cell division, though it doesn't affect how fast bladder cancer cells grow.
- - This discovery makes STAG2 one of the most frequently altered genes seen in bladder cancer cases, highlighting its potential role in understanding and treating the disease.
Article Abstract
Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875130 | PMC |
| http://dx.doi.org/10.1038/ng.2800 | DOI Listing |
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