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Editorial Commentary: Suture Tape Augmentation Enhances Recovery After Anterior Cruciate Ligament Surgery and Is Cost-Effective, While Biologic Augmentation Requires Well-Powered Controlled Trials.
Arthroscopy
September 2024
Columbia Orthopaedic Group.
Adding a biologic "mix" to facilitate anterior cruciate ligament (ACL) graft healing in bone tunnels is a promising option. Of course, optimization of graft healing in the femoral and tibial tunnels may or may not translate into a better biologic ACL graft. Specifically, after biologic tunnel augmentation, does the graft itself revascularize and remodel more rapidly to allow early return to sport earlier, which could justify the increased cost of biologic augmentation? This remains an unknown.
View Article and Find Full Text PDFUpper-edge subscapularis tendon tears associated with biceps instability are a cause of anterior shoulder pain and disability. At shoulder arthroscopy, the incidence of subscapularis pathology was noted to be 27%, with 47% of these being combined lesions involving the medial reflection pulley. The anatomic location of the upper subscapularis and biceps allows for combined fixation techniques.
View Article and Find Full Text PDFEnabling quantitative comparison of wastewater surveillance data across methods through data standardization without method standardization.
Sci Total Environ
November 2024
Water and Civil Engineering Division, Shinshu University, 4-17-1, Wakasato, Nagano 380-8553, Japan.
Wastewater surveillance for COVID-19 and other pathogens has expanded globally. Rapid development and availability of various assays has facilitated swift adoption of wastewater surveillance in localities with diverse requirements. However, it presents challenges in comparing data due to methodological variations.
View Article and Find Full Text PDFThe Hammersmith Score Optimises Patient Selection and Predicts for Overall Survival in Early-Phase Cancer Trial Participants Independent of Tumour Burden.
Chemotherapy
December 2024
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK.
Article Synopsis
- The Hammersmith Score (HS) is a validated prognostic tool that helps predict response and survival rates in early-phase cancer trial participants based on routine biochemical measures.
- A study analyzed 212 patient referrals, finding that HS significantly predicted overall survival and outperformed the Royal Marsden Score (RMS) in its predictive ability.
- HS offers a simple and cost-effective method to improve patient selection and referral for early-phase cancer trials, especially in the context of modern cancer immunotherapy.
Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management.
EBioMedicine
March 2024
Department of Clinical Neuroscience, Karolinska Institute, Solna, Sweden.
Neurofilament light chain (NfL) is a long-awaited blood biomarker that can provide clinically useful information about prognosis and therapeutic efficacy in multiple sclerosis (MS). There is now substantial evidence for this biomarker to be used alongside magnetic resonance imaging (MRI) and clinical measures of disease progression as a decision-making tool for the management of patients with MS. Serum NfL (sNfL) has certain advantages over traditional measures of MS disease progression such as MRI because it is relatively noninvasive, inexpensive, and can be repeated frequently to monitor activity and treatment efficacy.
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