AI Article Synopsis
- Sinomenine, an alkaloid from the Sinomenium acutum plant, is traditionally used in Chinese medicine for treating rheumatic arthritis.
- In recent studies, it showed moderate pain-relieving effects in normal rodents and was effective against hypersensitivity caused by inflammation and nerve injuries.
- Importantly, sinomenine’s analgesic effects occur without significant side effects and are not influenced by naloxone, indicating its unique mechanism of action.
Article Abstract
Sinomenine is an alkaloid originally isolated from the root of the plant Sinomenium acutum. It is used in traditional medicine in China to treat rheumatic arthritis. In the present study, we evaluated the potential antinociceptive effects of sinomenine in rodents with nociceptive, inflammatory and neuropathic pain. In normal rats and mice, systemic sinomenine produced moderate antinociceptive effect in the hot plate and tail flick tests. Sinomenine also exerted analgesic effects on mechanical and heat hypersensitivity in mice after carrageenan induced inflammation. Finally, sinomenine effectively alleviated mechanical and cold allodynia in rats and mice after injury to peripheral nerve or spinal cord. The analgesic effect of sinomenine is not associated with side effects and is not reversed by the opioid receptor antagonist naloxone. Our results showed that sinomenine has a wide spectrum analgesic effect in rodent models of nociceptive, inflammatory and neuropathic pain.
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| http://dx.doi.org/10.1016/j.ejphar.2013.09.062 | DOI Listing |
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