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Molecular scalpels dissect new GluN1 hot spots in anti-NMDA receptor encephalitis.
Sci Immunol
January 2025
IDIBAPS Biomedical Research Institute, Barcelona, Spain.
Patient-derived NMDAR mAbs combined with single-particle cryo-electron microscopy reveal multiple GluN1 epitopes and distinct functional effects.
View Article and Find Full Text PDFUltrasensitive detection of methylene blue by surface-enhanced Raman scattering (SERS) with Ag nanoparticle-decorated magnetic CoNi layered double hydroxides.
Anal Methods
January 2025
Key Laboratory of Oil and Gas Fine Chemicals Ministry of Education, Xinjiang Uyghur Autonomous Region, School of Chemical Engineering and Technology, Xinjiang University, Urumqi 830017, Xinjiang, China.
The unreasonable use of organic dye leads to excessive residues in environmental water, which seriously threatens human health and the natural environment. In this paper, a spherical flower-like magnetic FeO@CoNi layered double hydroxide@silver nanoparticle (FeO@CoNi LDH@Ag NPs) SERS substrate was successfully fabricated electrostatic self-assembly and applied for the sensitive detection of methylene blue (MB) in environmental water. The rapid concentration and separation of the SERS substrate from the water sample could be achieved using an external magnet.
View Article and Find Full Text PDFSurface-enhanced Raman scattering of R6G dimerization during self-healing of gel.
Mikrochim Acta
January 2025
Centre for Micro and Nano Devices, Department of Physics, COMSATS Institute of Information Technology, Islamabad, 44500, Pakistan.
Traditional surface-enhanced Raman scattering (SERS) substrates seeking uniformity and reproducibility of the Raman signal often assume and require that hot spots remain consistently stable during Raman testing. Recently, the non-uniform accumulation in SERS sample pre-concentration strategies have inspired the direct use of self-healing noble metal aerogels (NMAs), as the sample pretreatment presented in this work, and uncovered more diverse Raman information of substances during the dynamic process of laser irradiation. Rare characteristic peaks such as 820 cm⁻ for R6G within a specific concentration range were observed, and potential processes including R6G dimerization and desorption were analyzed.
View Article and Find Full Text PDFSources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation.
Ecotoxicol Environ Saf
December 2024
Chinese Academy of Geological Sciences, China Geology Survey, Ministry of Natural Resources, Beijing 100037, China.
This study investigates the pollution characteristics, spatial patterns, causes, and ecological risks of heavy metals in the soils of the southeastern Hubei polymetallic mining areas, specifically the Jilongshan (JLS) and Tonglushan (TLS) regions, located in the middle and lower reaches of the Yangtze River. The main findings are as follows: (1) Among the heavy metals present in the soil, copper (Cu) has the highest average concentration at 278.54 mg/kg, followed by zinc (Zn) at 161.
View Article and Find Full Text PDFProbing the Local Field Enhancement Using SERS Detection of DNA Strands with Different Lengths and Grafting Strategies on Graphene Oxide Plasmonic Nanoplatforms.
J Phys Chem Lett
December 2024
Biomolecular Physics Department, Faculty of Physics, Babeş-Bolyai University, 1 M. Kogalniceanu Str., 400084 Cluj-Napoca, Romania.
Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful tool for analyzing nucleic acids due to its exceptional sensitivity and specificity. This study rigorously investigates not only the impact of polyA strands of different lengths (, 5, 10, 15, and 20 adenine bases) but also their distinct grafting strategy (SH at 5' and NH at 5' end) on the SERS signal of DNA strand using synthesized gold nanoparticles (AuNPs) on graphene oxide sheets (GO-AuNPs). By comparing the thiol vs amine bonding onto the GO-AuNP nanoplatform, we found a strong correlation between the adenine peak intensity at 732 cm and the strand length for both grafting methods (SH at 5' end or NH at 5' end).
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