AI Article Synopsis
- The distribution of organelles within cells is not random but is organized and constrained by the cytoskeleton and adaptor proteins, which is crucial for proper cell function.
- Recent research shows that this polarization of organelles also occurs in T lymphocytes, not just in neurons and epithelial cells.
- The review discusses how organelle redistribution is affected by T cell activation and immune synapse formation, emphasizing its role in early T cell activation and signal transmission to the nucleus.
Article Abstract
To ensure proper cell function, intracellular organelles are not randomly distributed within the cell, but polarized and highly constrained by the cytoskeleton and associated adaptor proteins. This relationship between distribution and function was originally found in neurons and epithelial cells; however, recent evidence suggests that it is a general phenomenon occurring in many highly specialized cells including T lymphocytes. Recent studies reveal that the orchestrated redistribution of organelles is dependent on antigen-specific activation of and immune synapse (IS) formation by T cells. This review highlights the functional implications of organelle polarization in early T cell activation and examines recent findings on how the IS sets the rhythm of organelle motion and the spread of the activation signal to the nucleus.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347664 | PMC |
| http://dx.doi.org/10.1016/j.tcb.2013.09.005 | DOI Listing |
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