Objective: This study investigated the effectiveness and safety of topical application of diosmectite (DS) and basic fibroblast growth factor (bFGF) paste in the treatment of minor recurrent aphthous stomatitis.
Study Design: Four pastes, containing bFGF and DS, DS alone, bFGF alone, and vehicle only, were consecutively applied 4 times per day for 5 days. Pain levels and the amount of ulcer amelioration were evaluated.
Results: A total of 129 participants completed the study. DS+bFGF paste released bFGF continuously and significantly lowered ulcer pain scores (P < .05 for days 3, 4, 5, and 6) compared with the other pastes. The ulcer size was significantly reduced (P < .05 for days 2, 4, and 6) in the DS+bFGF paste group compared with the other groups. No obvious adverse drug effects were observed.
Conclusions: DS+bFGF paste was effective in alleviating ulcer pain and promoting healing without significant side effects in the treatment of minor recurrent aphthous stomatitis.
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| http://dx.doi.org/10.1016/j.oooo.2013.07.003 | DOI Listing |
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