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MYCN-amplified spinal ependymomas: a rare aggressive subtype. Illustrative cases.
J Neurosurg Case Lessons
January 2025
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Background: Spinal ependymomas are typically slow-growing tumors with a favorable prognosis. Recently, a new aggressive subtype has emerged with its own distinct histopathological and molecular features characterized by MYCN amplification. However, this subtype of spinal ependymoma is rare, and studies on its imaging characteristics are limited.
View Article and Find Full Text PDFRecent trends and impact of localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS) in modern analysis.
J Pharm Anal
November 2024
Department of Pharmaceutical Analysis, ISF College of Pharmacy Moga, 142001, Punjab, India.
An optical biosensor is a specialized analytical device that utilizes the principles of optics and light in bimolecular processes. Localized surface plasmon resonance (LSPR) is a phenomenon in the realm of nanophotonics that occurs when metallic nanoparticles (NPs) or nanostructures interact with incident light. Conversely, surface-enhanced Raman spectroscopy (SERS) is an influential analytical technique based on Raman scattering, wherein it amplifies the Raman signals of molecules when they are situated near specific and specially designed nanostructures.
View Article and Find Full Text PDFHuman Auditory-Motor Networks Show Frequency-Specific Phase-Based Coupling in Resting-State MEG.
Hum Brain Mapp
January 2025
Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.
Perception and production of music and speech rely on auditory-motor coupling, a mechanism which has been linked to temporally precise oscillatory coupling between auditory and motor regions of the human brain, particularly in the beta frequency band. Recently, brain imaging studies using magnetoencephalography (MEG) have also shown that accurate auditory temporal predictions specifically depend on phase coherence between auditory and motor cortical regions. However, it is not yet clear whether this tight oscillatory phase coupling is an intrinsic feature of the auditory-motor loop, or whether it is only elicited by task demands.
View Article and Find Full Text PDFSelf-amplifying RNA virus vectors for drug delivery.
Expert Opin Drug Deliv
January 2025
PanTherapeutics, Lutry, Switzerland.
Introduction: Viral vectors have proven useful for delivering genetic information, such as drugs and vaccines, for therapeutic and prophylactic interventions. Self-amplifying RNA viruses possess the special feature of high-level RNA amplification in the host cell cytoplasm providing high antigen production against infectious pathogens and various types of cancers, and expression of anti-tumor genes, toxic genes, and immunostimulatory genes.
Areas Covered: Self-amplifying RNA viral vectors have been evaluated in animal models and clinical trials for immune responses and protection against challenges with pathogenic infectious agents and tumor cells.
Social Media Recruitment as a Potential Trigger for Vulnerability: Multistakeholder Interview Study.
JMIR Hum Factors
December 2024
Institute of History and Ethics in Medicine, TUM School of Medicine and Health, Technical University of Munich, Ismaningerstr. 22, Munich, 81675, Germany, 49 89 4140 4041.
Background: More clinical studies use social media to increase recruitment accrual. However, empirical analyses focusing on the ethical aspects pertinent when targeting patients with vulnerable characteristics are lacking.
Objective: This study aims to explore expert and patient perspectives on vulnerability in the context of social media recruitment and seeks to explore how social media can reduce or amplify vulnerabilities.
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