AI Article Synopsis
- * Researchers created two mouse models: transgenic mice with increased MPDZ expression and knockout heterozygote mice with reduced expression, both of which showed different responses to ethanol withdrawal compared to regular mice.
- * The findings indicate that lower levels of MPDZ are associated with more severe ethanol withdrawal and reduced ethanol consumption, suggesting that MPDZ plays a significant role in how organisms respond to alcohol.
Article Abstract
Association studies implicate multiple PDZ domain protein (MPDZ/MUPP1) sequence and/or expression in risk for alcoholism in humans and ethanol withdrawal (EW) in mice, but confirmation has been hindered by the dearth of targeted genetic models. We report the creation of transgenic (MPDZ-TG) and knockout heterozygote (Mpdz(+/-) ) mice, with increased (2.9-fold) and decreased (53%) target expression, respectively. Both models differ in EW compared with wild-type littermates (P ≤ 0.03), providing compelling evidence for an inverse relationship between Mpdz expression and EW severity. Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997615 | PMC |
| http://dx.doi.org/10.1111/adb.12087 | DOI Listing |
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