Despite enormous efforts that have been made in the search for novel drugs and treatments, cancer continues to be a major public health problem. Moreover, the emergence of resistance to cancer chemotherapy often prevents complete remission. Researchers have thus turned to natural products mainly from plant origin to circumvent resistance. Pectin and pH- or heat-modified pectin have demonstrated chemopreventive and antitumoral activities against some aggressive and recurrent cancers. The focus of this review is to describe how pectin and modified pectin display these activities and what are the possible underlying mechanisms. The failure of conventional chemotherapy to reduce mortality as well as serious side effects make natural products, such as pectin-derived products, ideal candidates for exerting synergism in combination with conventional anticancer drugs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792700 | PMC |
| http://dx.doi.org/10.3389/fphar.2013.00128 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-resolution mass spectrometry unveils the molecular changes of ovalbumin induced by heating and their influence on IgE binding capacity.
Food Chem
November 2022
INRAE, UR1268 BIA, F-44316 Nantes, France; INRAE, PROBE Research Infrastructure, BIBS Facility, F-44316 Nantes, France.
Ovalbumin (OVA) is a food allergen whose allergenicity is modulated by heating. We aimed to establish a molecular connection between heat-induced structural modifications and the modulation of the IgE binding capacity of OVA. For this, we used model samples of heat-modified OVA with increasing complexity; glycated, aggregated, or glycated and aggregated.
View Article and Find Full Text PDFCitrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation.
J Biol Chem
August 2021
Engineering Research Center of Glycoconjugates Ministry of Education, Jilin Province Key Laboratory on Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University, Changchun, China. Electronic address:
Heat-modified citrus pectin, a water-soluble indigestible polysaccharide fiber derived from citrus fruits and modified by temperature treatment, has been reported to exhibit anticancer effects. However, the bioactive fractions and their mechanisms remain unclear. In this current study, we isolated an active compound, trans-4,5-dihydroxy-2-cyclopentene-l-one (DHCP), from heat-treated citrus pectin, and found that is induces cell death in colon cancer cells via induction of mitochondrial ROS.
View Article and Find Full Text PDFSimultaneous recovery of ammonium and total phosphorus from toilet tail water by modified palygorskite-bentonite clay.
Water Environ Res
July 2021
School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, China.
Suitable treatment of toilet sewage is a worldwide challenge. The anaerobic baffled reactor (ABR)-microbial fuel cell (MFC)-microbial electrolysis cell (MEC) (AMM) coupling treatment system has been constructed achieving effective removal of carbon, nitrogen, and phosphorus from toilet sewage and resource recovery; however, ammonium (NH -N) and total phosphorus (TP) accumulation in tail water is a found problem of the system. In this study, acid-modified and alkali-heat modified palygorskite-bentonite (Pal-Ben) were used to recover NH -N and TP from the AMM toilet tail water simultaneously.
View Article and Find Full Text PDFCo-remediation of Pb Contaminated Soils by Heat Modified Sawdust and Festuca arundinacea.
Sci Rep
March 2020
Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollution, School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
This research aimed to explore the potential and mechanism of heat modified sawdust combined with Festuca arundinacea for the remediation of Pb-contaminated soil. We determined Pb concentration and biochemical indices in plants and soils, analyzed microbial communities in soil, and studied Pb distribution in subcellular and tissues. Under co-remediation of 5% material addition and Festuca arundinacea, the concentration of Pb in soil decreased.
View Article and Find Full Text PDFEmulsifying properties of glycation or glycation-heat modified egg white protein.
Food Res Int
May 2019
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; School of Food Science, Jiangnan University, Wuxi, Jiangsu 214122, PR China. Electronic address:
To investigate the potential of glycation and/or heat modified egg white protein (EWP) as stabilizer for oil-in-water emulsions, glycated EWP (GEWP) was prepared by a dry-heated Maillard reaction using EWP and isomalto-oligosaccharide. Heat-induced GEWP nanoparticles (HGN) were then fabricated by heating GEWP at 90 °C for 30 min at pH 6.0-9.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!