The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

Chembiochem

Lehrstuhl Chemie der Biopolymere, Technische Universität München and Munich Center For Integrated Protein Science (CIPSM), Weihenstephaner Berg 3, 85354 Freising (Germany); Current address: Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg (Germany).

Published: October 2013

Wobbly backbone: The backbone dynamics of the amyloid precursor protein (APP) transmembrane helix was compared to those of other transmembrane domains. In contrast to expectation, no above-average backbone dynamics was found for the APP transmembrane helix; the dynamics thus appears not to be optimized for cleavage.

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http://dx.doi.org/10.1002/cbic.201300322DOI Listing

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