In this article, we evaluated the electrophysiological performance of a novel, high-complexity silicon probe array. This brain-implantable probe implements a dynamically reconfigurable voltage-recording device, coordinating large numbers of electronically switchable recording sites, referred to as electronic depth control (EDC). Our results show the potential of the EDC devices to record good-quality local field potentials, and single- and multiple-unit activities in cortical regions during pharmacologically induced cortical slow wave activity in an animal model.

Download full-text PDF

Source
http://dx.doi.org/10.1515/bmt-2012-0102DOI Listing

Publication Analysis

Top Keywords

electronic depth
8
depth control
8
vivo validation
4
validation electronic
4
control probes
4
probes article
4
article evaluated
4
evaluated electrophysiological
4
electrophysiological performance
4
performance novel
4

Similar Publications

Introduction: Persistent knee pain often due to knee osteoarthritis (OA) is a highly prevalent and disabling condition. Electronic-rehabilitation (e-rehab) programmes have the potential to support self-management of knee OA. This study aimed to evaluate user engagement and acceptability of two e-rehab programmes, Group e-rehab, a remote physiotherapy-led programme and My Knee UK, a self-directed web-based exercise programme.

View Article and Find Full Text PDF

Exploring the relationship between MGAT2 and glioblastoma: A Mendelian Randomization and bioinformatics approach.

Brain Res

January 2025

Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Background: Mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2 (MGAT2) and tumors' relevant research was in full swing recently. Therefore, we employed Mendelian Randomization (MR) alongside bioinformatics to thoroughly investigate the possible relationship between MGAT2 and glioblastoma (GBM).

Methods: We utilized the summary statistics of genome-wide association studies (GWAS) for MGAT2 (N = 35,559 from deCODE) and glioblastoma (N = 379,155 from FinnGen).

View Article and Find Full Text PDF

Complications of percutaneous coronary intervention.

Prog Cardiovasc Dis

January 2025

Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, MN, USA. Electronic address:

Complications of percutaneous coronary intervention (PCI) can lead to significant morbidity and mortality. In-depth understanding of the mechanisms and management options of these complications as well as timely recognition and action can sometimes be lifesaving. In this review we discuss the mechanisms, prevention methods, diagnosis, and management of three major PCI complications: a) perforation b) acute vessel closure, and c) equipment loss.

View Article and Find Full Text PDF

The trait-specific timing of accelerated genomic change in the human lineage.

Cell Genom

January 2025

Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA; Department of Statistics and Data Science, The University of Texas at Austin, Austin, TX, USA. Electronic address:

Humans exhibit distinct characteristics compared to our primate and ancient hominin ancestors. To investigate genomic bursts in the evolution of these traits, we use two complementary approaches to examine enrichment among genome-wide association study loci spanning diseases and AI-based image-derived brain, heart, and skeletal tissue phenotypes with genomic regions reflecting four evolutionary divergence points. These regions cover epigenetic differences among humans and rhesus macaques, human accelerated regions (HARs), ancient selective sweeps, and Neanderthal-introgressed alleles.

View Article and Find Full Text PDF

Attracting nursing talent to the intensive care unit: A qualitative study on how to create an appealing work environment.

Intensive Crit Care Nurs

January 2025

Departament d'Infermeria Fonamental i Clínica, Faculty of Nursing, Universitat de Barcelona, Carrer de la Feixa Llarga, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.

Introduction And Objective: The global shortage of nurses who want to work in the intensive care unit (ICU) is alarming, putting at risk quality of care and patient safety. With efforts put into engagement strategies, optimized recruitment programmes are scarce, specifically in the ICU setting. The aim of this study is to describe and explore ICU nurses' opinions on their work motivational factors that influenced the decision to work in the ICU setting.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!