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Chronic Radium-226 toxicity to and oxidative stress in the aquatic invertebrate .
Toxicol Res (Camb)
February 2025
Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK S7N 5B3, Canada.
The mining industry, including uranium mining and milling, is of high importance in Canada. It is, however, important to consider that ore processing can result in the creation of by-products that contain radionuclides such as radium-226 (Ra). Even with the strict discharge regulations in place, there is limited evidence to suggest that the current Canadian regulatory thresholds for Ra are protective for aquatic life.
View Article and Find Full Text PDFElevating Red and Near-Infrared Detectivity With CsSnI Perovskite Photodetectors Featuring GO and PCBM as Charge Transport Layers.
Luminescence
January 2025
Department of Electronics and Communication Engineering, Madan Mohan Malaviya University of Technology, Gorakhpur, Uttar Pradesh, India.
This study focuses on enhancing the performance of photodetector through the utilization of inorganic perovskite material. It emphasizes that the unique properties of perovskite materials contribute to the superior performance of the photodetector. The focus is on the design and enhancement of CsSnI-based photodetector having graphene oxide (GO) and PCBM as charge transport layer, analysing their potential for improved operation.
View Article and Find Full Text PDF"Cofactors" for Natural Products.
ChemMedChem
January 2025
National Taiwan University, Chemistry, No.1, Sec.4, Roosevelt Road, Deptartment of Chemistry, Rm A521, 106319, Taipei, TAIWAN.
Cofactors are non-protein entities necessary for proteins to operate. They provide "functional groups" beyond those of the 20 canonical amino acids and enable proteins to carry out more diverse functions. Such a viewpoint is rarely mentioned, if at all, when it comes to natural products and is the theme of this Concept.
View Article and Find Full Text PDFComparing the Effect of Heat Therapy and Mitochondrial-Targeted Antioxidants in Polycystic Ovarian Syndrome Phenotype Induced by Junk Food Consumption.
Reprod Sci
January 2025
Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Polycystic ovarian syndrome (PCOS) is a complex endocrine-metabolic disorder, and multiple factors contribute to its pathophysiology. The current study assessed a PCOS-like animal model induced by consuming a high-fat sugar (HFHS) diet and compared the treatment outcome of mitochondrial-targeted antioxidants versus heat therapy. Sixty rats were divided into the following study groups: three control groups (negative and positive for the treatments used), HFHS, hot tub therapy (HTT) treatment, and MitoQ10 treatment (500 µmol/L MitoQ10 in clean drinking water daily, from week fourteen till week twenty-two of the study).
View Article and Find Full Text PDFMetastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies.
PLoS One
January 2025
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Metastatic melanoma causes a high rate of mortality. We conducted an integrated analysis to identify critical regulators associated with the prognosis, pathogenesis, and targeted therapies of metastatic-melanoma. A microarray dataset, GSE15605, including 12 metastatic-melanoma and sixteen normal skin (NS) samples, were obtained from the GEO database.
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