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Adjunctive intravascular lithotripsy for heavily calcified carotid stenosis: a dual-center experience and technical case series.
J Neurointerv Surg
January 2025
Neurosurgery, Gates Vascular Institute, Buffalo, New York, USA
Article Synopsis
- Heavily calcified carotid stenosis (HCCS) has traditionally been challenging to treat with carotid angioplasty and stenting (CAS), but this study explores the use of the Shockwave S intravascular lithotripsy (IVL) system as a potential solution.
- A retrospective analysis of 17 procedures combining IVL and CAS on patients with HCCS showed technical success in all cases and significant reductions in stenosis levels post-procedure.
- The results indicated that the combined approach is safe, with a low major adverse event (MAE) rate and a promising outcome in managing both symptomatic and asymptomatic patients with HCCS.
Avoiding Complications with Transcarotid Artery Revascularization.
Ann Vasc Surg
September 2024
Department of Vascular and Endovascular Surgery, Geisinger Medical Center, Danville, PA.
Background: Transcarotid artery revascularization (TCAR) for carotid artery stenting offers an innovative method for treating carotid artery occlusive disease. This technique utilizes the ENROUTE Transcarotid Neuroprotection System (Silk Road Medical, Sunnyvale, CA) to temporarily reverse flow in the carotid artery prior to crossing or treating the carotid lesion, reducing the perioperative risk of stroke. This review aims to summarize possible complications associated with the procedure and offer suggestions to address or avoid these issues in practice.
View Article and Find Full Text PDFSilencing of mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission.
Acta Biochim Biophys Sin (Shanghai)
September 2024
Department of Cardiology, the General Hospital of Western Theater Command, Chengdu 610083, China.
The pathological proliferation and migration of vascular smooth muscle cells (VSMCs) are key processes during vascular neointimal hyperplasia (NIH) and restenosis. Phosphoenolpyruvate carboxy kinase 1 (PCK1) is closely related to a variety of malignant proliferative diseases. However, the role of PCK1 in VSMCs has rarely been investigated.
View Article and Find Full Text PDFForearm access for carotid artery stenting using the dual protection of flow reversal and distal filter: Trans-forearm dual protection technique.
Interv Neuroradiol
August 2024
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.
Background: Although transfemoral carotid artery stenting (CAS) is widely performed for carotid stenosis, serious or even fatal complications such as embolic and access site complications can still occur. We devised a novel dual protection system with continuous flow reversal to the cephalic vein of the forearm in transradial CAS, referred to as the "trans-forearm dual protection" technique.
Methods: A 75-year-old man with a diagnosis of symptomatic left cervical internal carotid artery (ICA) stenosis underwent CAS using the trans-forearm dual protection technique.
miR-1290 induces endothelial-to-mesenchymal transition and promotes vascular restenosis after angioplasty by targeting FGF2.
Atherosclerosis
September 2024
Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China. Electronic address:
Background And Aims: Endothelial-to-mesenchymal transition (EndMT) is an important reason for restenosis but the underlying mechanisms need to be further explored. Therefore, the purpose of this study is to screen significantly different microRNAs (miRNAs) and assess their functions and downstream pathways.
Methods: This study screened several miRNAs with significant differences between human arterial segments from restenosis patients and healthy volunteers using whole transcriptome resequencing and real-time quantitative reverse transcription PCR (qRT-PCR).
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