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meningitis in a patient with newly diagnosed acquired immunodeficiency syndrome from Sikkim, India.
Curr Med Mycol
May 2024
Department of Microbiology, Sikkim Manipal Institute of Medical Science, Gangtok, India.
Background And Purpose: infections in India have shifted, with an increase in the incidence rate of invasive candidiasis, particularly due to non- species. The central nervous system infections by are sparsely reported and more understanding and research is needed regarding these infections.
Case Report: This study reported an unusual case of meningitis in a middle-aged female with pulmonary tuberculosis and newly diagnosed acquired immunodeficiency syndrome with a low cluster of differentiation 4 count (12 cells/mm).
Mortality patterns in candidemia: Insights from a multispecies analysis using a global research network.
Med Mycol
December 2024
Department of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Understanding the impact of different Candida species on patient outcomes is crucial for effective management and treatment strategies. This study aims to comprehensively analyze the association between Candida species and mortality in documented candidemia. We queried TriNetX, a global research network database, to identify patients diagnosed with candidemia through polymerase chain reaction from 2020 to 2023.
View Article and Find Full Text PDFMitochondrial targeting of SPFH proteins and requirement of stomatins for SDS-induced stress tolerance.
Microbiol Spectr
January 2025
Department of Sciences, John Jay College of the City University of New York, New York, New York, USA.
Unlabelled: The SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast , stomatin-like protein 3 (Slp3) forms punctate foci at the plasma membrane, and overexpression causes cell death following exposure to the surfactant, SDS, and the oxidative stressor, HO.
View Article and Find Full Text PDFRisk factors associated with short-term mortality in patients with candidemia and the predictive value of serum cytokine level.
Cytokine
January 2025
Department of Infectious Diseases, Tongling People's Hospital, Tongling 244000, China.
Background: Some pro-inflammatory and anti-inflammatory cytokines were significantly elevated in patients with candidemia patients, but no studies have included these cytokines in the analysis of risk factors for mortality of candidemia. This study aims to analyze the risk factors of short-term mortality of candidemia and the predictive value of serum cytokines.
Methods: We retrospectively analyzed and compared the clinical features, risk factors and cytokine interleukin (IL)-6, interferon-γ (IFN-γ), IL-10 and IL-17 between survival group and death group in 53 patients with candidemia.
Rezafungin versus caspofungin for patients with candidaemia or invasive candidiasis in the intensive care unit: pooled analyses of the ReSTORE and STRIVE randomised trials.
Crit Care
October 2024
Médecine Intensive Réanimation, Inserm U1285, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CHU de Lille, Université de Lille, Lille, France.
Background: Rezafungin is an echinocandin approved in the US and EU to treat candidaemia and/or invasive candidiasis. This post-hoc, pooled analysis of the Phase 2 STRIVE and Phase 3 ReSTORE trials assessed rezafungin versus caspofungin in patients with candidaemia and/or invasive candidiasis (IC) in the intensive care unit (ICU) at randomisation.
Methods: STRIVE and ReSTORE were randomised double-blind trials in adults with systemic signs and mycological confirmation of candidaemia and/or IC in blood or a normally sterile site ≤ 96 h before randomisation.
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