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Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells. | LitMetric

Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells.

Org Lett

Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States, and Division of Immunology and Allergy, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

Published: October 2013

The relationship between mold and asthma has been recognized for decades, but the molecular triggers of asthma generated by molds have not been fully elucidated. A glycolipid generated by Aspergillus species has recently been identified that triggers airway hyperreactivity via natural killer T cell activation. The synthesis of this glycolipid and structural variants designed to allow identification of the features of this glycolipid required for recognition by natural killer T cells is described.

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Source
http://dx.doi.org/10.1021/ol4024375DOI Listing

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