Detection of spines in medical images are important tasks in medical applications. These tasks are relatively easy for CT/MR images because the bones are easily distinguishable from other tissues. However, they are difficult for x-ray images due to bone and soft tissue overlapping. This paper illustrates a method for detecting the medial axis of spine in x-ray images. Given an initial point on the spine in the x-ray image manually or automatically, the method iteratively searches for good feature points on the spine to locate the medial axis. As a result, the effort of determining the relevant medical information, such as Cobb's angle, can be minimized. The proposed method is fast and efficient. In average it took less than 1 second for localizing the spine on a 3000×1000 gray scale x-ray image.
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http://dx.doi.org/10.1109/EMBC.2013.6610693 | DOI Listing |
Alzheimers Res Ther
January 2025
Laboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Crta M40, km38, Madrid, 28223, Spain.
Background: Dementia patients commonly present multiple neuropathologies, worsening cognitive function, yet structural neuroimaging signatures of dementia have not been positioned in the context of combined pathology. In this study, we implemented an MRI voxel-based approach to explore combined and independent effects of dementia pathologies on grey and white matter structural changes.
Methods: In 91 amnestic dementia patients with post-mortem brain donation, grey matter density and white matter hyperintensity (WMH) burdens were obtained from pre-mortem MRI and analyzed in relation to Alzheimer's, vascular, Lewy body, TDP-43, and hippocampal sclerosis (HS) pathologies.
Biomark Res
January 2025
Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Background: Up to 23% of breast cancer patients recurred within a decade after trastuzumab treatment. Conversely, one trial found that patients with low HER2 expression and metastatic breast cancer had a positive response to trastuzumab-deruxtecan (T-Dxd). This indicates that relying solely on HER2 as a single diagnostic marker to predict the efficacy of anti-HER2 drugs is insufficient.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Objectives: To construct a prediction model based on deep learning (DL) and radiomics features of diffusion weighted imaging (DWI), and clinical variables for evaluating TP53 mutations in endometrial cancer (EC).
Methods: DWI and clinical data from 155 EC patients were included in this study, consisting of 80 in the training set, 35 in the test set, and 40 in the external validation set. Radiomics features, convolutional neural network-based DL features, and clinical variables were analyzed.
BMC Med Educ
January 2025
Department of Spine Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Background: Adolescent idiopathic scoliosis, a complex three-dimensional spine deformity, presents a formidable challenge for orthopedic residents in understanding its anatomy and surgical strategies. The aim of this study is to investigate the impact of three-dimensional printing (3DP) models in enhancing the comprehension of adolescent idiopathic scoliosis among orthopedic residents.
Methods: Forty orthopedic residents were randomly divided into two groups, the first group received lectures that were augmented with 3DP models illustrating five cases of adolescent idiopathic scoliosis, along with corresponding X-ray and CT images.
BMC Ophthalmol
January 2025
Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.
Background: Cutaneous melanoma is the leading cause of death from cutaneous malignancy and tends to metastasize lymphatically and hematogenously to the lung, liver, brain, and bone; it is a rare source of metastatic disease to the eye. Herein we provide a case report of cutaneous melanoma metastatic to the ciliary body and choroid involving clinical examination, slit lamp photography, and B-scan ultrasonography.
Result: A 55-year-old female with known metastatic cutaneous melanoma presented with pain, a large ciliochoroidal mass, visual decline, and diffuse intraocular inflammation.
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