Falls prevention is important for older individuals to maintain healthy lifestyles and is an essential challenge in sustaining the socioeconomic structure of many advanced nations. Tripping has been recognized as the largest cause of falls and accordingly, understanding tripping-induced anterior balance loss is necessary in reducing the overall frequency of falls among older adults. Hazardous anterior balance loss due to tripping can be attributed to the mid-swing phase event, minimum foot clearance (MFC). The mechanism of tripping-induced anterior balance loss can be described as anterior movement of the center of mass (CoM) passing the frontal boundary of the supporting base between the swing and stance toes. The first aim of the current study was to establish a computational method for determining available response time (ART) to anterior balance loss due to tripping at MFC, in other words, the time taken for CoM to reach the anterior boundary and therefore, the time limit for balance recovery. Kinematic information of CoM and both toes in addition to simulated impact force due to tripping at MFC were used to estimate ART. The second aim was to apply correlation analysis to a range of gait parameters to identify the factors influencing ART. ART for balance loss in the forward direction due to tripping was on average. 0.11s for both the dominant and non-dominant limbs' simulated tripping at MFC. Correlation analysis revealed five factors at MFC that prolong ART including: 1) greater fore-aft distance from CoM to stance toe, 2) greater sideway distance from CoM to swing toe, 3) longer distance from CoM to the frontal boundary of the supporting base, 4) slower CoM forward velocity and 5) slower horizontal toe velocity. The established ART computation method can be utilized to examine the effects of ageing and various gait tasks on the likelihood of tripping-induced anterior balance loss and associated falls.
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http://dx.doi.org/10.1109/EMBC.2013.6610646 | DOI Listing |
Psychopharmacology (Berl)
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Rationale: One of the most debilitating drawbacks of cisplatin chemotherapy is neurotoxicity which elicits memory impairment and cognitive dysfunction (chemobrain). This is primarily triggered by oxidative stress and inflammation. Captopril, an angiotensin-converting enzyme inhibitor, has been reported as a neuroprotective agent owing to its antioxidant and anti-inflammatory effects.
View Article and Find Full Text PDFSci Rep
January 2025
School of Mathematics and Computer Science, Zhejiang A&F University, Hangzhou, 311300, Zhejiang, China.
Urban expansion has triggered significant changes in soil organic carbon (SOC), profoundly affecting the global carbon cycle. The accurate prediction of the global distribution of urban SOC and assessment of the impact of future urban expansion on SOC are essential for urban soil carbon management. By using data from 377 urban locations, this study estimated the global distribution of urban SOC and projected future SOC changes under two socioeconomic scenarios: SSP126 and SSP585.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Internal Medicine, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India.
Phenytoin is one of the most used antiepileptic drugs. Isoniazid, a first-line antitubercular drug, blocks the CYP2C19 enzyme, preventing phenytoin from being metabolised. Concomitant use of phenytoin and isoniazid predisposes to phenytoin toxicity.
View Article and Find Full Text PDFSci Total Environ
January 2025
Ministry of Earth Science, New Delhi 110003, India.
Glaciers of Jammu and Kashmir are retreating faster than those in the broader northwestern Himalayas, yet some glaciers in the Chenab River basin display signs of periodic advancement and mass gain (2005-2007). These features, such as coalescing lobate structures and blocked meltwater streams, raise intriguing questions about localized glacier dynamics. While global concerns over climate change and glacier retreat persist, the lack of detailed evidence regarding glacier advance in this region warrants further investigation.
View Article and Find Full Text PDFJAMA
January 2025
Indiana University, Bloomington.
Importance: Osteoporotic fractures are associated with psychological distress, subsequent fractures, loss of independence, reduced ability to perform activities of daily living, and death.
Objective: The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the evidence on the benefits and harms of screening for osteoporosis to prevent fractures in adults 40 years or older with no known diagnosis of osteoporosis or history of fragility fracture.
Population: Adults 40 years or older without known osteoporosis or history of fragility fractures.
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