Molecular delivery into localized NIH/3T3 cells was achieved with microbubbles produced by laser pulses focused on an optically absorbent substrate. The laser-induced bubble expansion and contraction resulted in cell poration. The microbubbles are localized at the laser focal point, so molecular delivery can be directed at specific localized cells. This was demonstrated with the delivery of 3-kDa FITC-Dextran. Single-cell molecular delivery was achieved, even in the presence of nearby cells. The efficiency of the cell poration was up to 95%, with a corresponding cell viability of 98%.
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