AI Article Synopsis
- A new method for quickly obtaining interstitial fluid (ISF) samples using a special jet injector has been tested on pig tissue.
- The injector first injects a small saline solution to pierce the skin and then uses a vacuum to collect the ISF.
- Researchers optimized the process to minimize sample dilution, achieving a 3.5% ISF concentration within just over 3 seconds.
Article Abstract
The feasibility of a new method of quickly acquiring interstitial fluid (ISF) samples using a Lorentz-force actuated needle-free jet injector is demonstrated on ex vivo porcine tissue. The jet injector is used to first inject a small volume of physiological saline to breach the skin, and the back-drivability of the actuator is utilized to create a vacuum in the ampoule and collect ISF. Injection and extraction parameters are tested and optimized for minimal acquired sample dilution and extracted volume consistency. Using this method, we are able to collect a sample that contains up to 3.5% ISF in 3.1 s.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/EMBC.2013.6610294 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Near-Field Mixing in a Coaxial Dual Swirled Injector.
Flow Turbul Combust
November 2024
Institut de Mécanique des Fluides de Toulouse, IMFT, CNRS, Université de Toulouse, Toulouse, France.
Improving mixing between two coaxial swirled jets is a subject of interest for the development of next generations of fuel injectors. This is particularly crucial for hydrogen injectors, where the separate introduction of fuel and oxidizer is preferred to mitigate the risk of flashback. Raman scattering is used to measure the mean compositions and to examine how mixing between fuel and air streams evolves along the axial direction in the near-field of the injector outlet.
View Article and Find Full Text PDFJet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice.
Vaccines (Basel)
January 2025
State Research Center of Virology and Biotechnology "Vector", Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.
Although mRNA vaccines encapsulated in lipid nanoparticles (LNPs) have demonstrated a safety profile with minimal serious adverse events in clinical trials, there is opportunity to further reduce mRNA reactogenicity. The development of naked mRNA vaccines could improve vaccine tolerability. Naked nucleic acid delivery using the jet injection method may be a solution.
View Article and Find Full Text PDFUsage of double injector for efficient mixing of the fuel behind the ramp injector at supersonic combustion chamber.
Sci Rep
January 2025
Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran.
This investigation presents extensive computational analyses of the compressible flow near ramp injector with double circular injectors at supersonic combustor of scramjet engine. Comparison of the fuel mixing and fuel jet penetration of hydrogen jet are done for two injector configurations at free stream Mach number of 2. The simulation of the supersonic flow near ramp injector is done via solving RANS equations with computational fluid dynamic technique.
View Article and Find Full Text PDFImproved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods.
Cell Biosci
December 2024
Department of Pathology, Johns Hopkins School of Medicine, CRB II Room 307, 1550 Orleans St, Baltimore, MD, USA.
Background: We have previously developed a candidate therapeutic HPV DNA vaccine (pBI-11) encoding mycobacteria heat shock protein 70 linked to HPV16/18 E6/E7 proteins for the control of advanced HPV-associated oropharyngeal cancer (NCT05799144). While naked DNA vaccines are readily produced, stable, and well tolerated, their potency is limited by the delivery efficiency. Here we compared three different IM delivery strategies, including intramuscular (IM) injection, either with a needle alone or with electroporation at the injection site, and a needle-free injection system (NFIS), for their ability to elicit gene expression and to improve the potency of pBI-11 DNA vaccine.
View Article and Find Full Text PDFEfficacy and Safety of Needle-Free Microjet Injection Versus Needle Injection of Botulinum Toxin for the Treatment of Crow's Feet: A Randomized Split-Face Pilot Study.
Ann Dermatol
December 2024
Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
Background: Botulinum toxin is commonly used for cosmetic enhancements in various applications. However, the pain experienced during the injection process remains a significant concern.
Objective: This study aimed to evaluate the effectiveness and safety of a needle-free microjet drug injector, powered by an Er:YAG laser, for the injection of botulinum toxin to treat crow's feet wrinkles.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!