A measuring device for human abdominal fat from the conductivity image derived by electrical impedance tomography (EIT) is rarely found. This study was aimed to reconstruct precise conductivity images from multiple voltage measurements in different patterns of the combination of current and voltage electrodes. We examined two voltage measuring patterns using electrodes located at upper and lower levels around the abdomen of a subject. In the experiment, after 1024 voltage data were taken from one specified voltage measurement pattern, another 1024 data were also taken continuously using another pattern. The reconstruction of conductivity image was made using entire data. As a result, the tomography image was improved compared with the image obtained from single voltage measurement pattern. We then obtained the histogram of the conductivities and estimated the area of abdominal fat. The present method using multiple voltage measurement patterns would be effective, if the measuring time can be much reduced through future modification of the tomography device.
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http://dx.doi.org/10.1109/EMBC.2013.6610246 | DOI Listing |
The big potassium (BK) channels remain open with a small limiting probability of ∼ 10 at minimal Ca and negative voltages < -100 mV. The molecular origin and functional significance of such "intrinsic opening" are not understood. Here we combine atomistic simulations and electrophysiological experiments to show that the intrinsic opening of BK channels is an inherent property of the vapor barrier, generated by hydrophobic dewetting of the BK inner pore in the deactivated state.
View Article and Find Full Text PDFAnal Methods
January 2025
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Adenosine triphosphate (ATP) is crucial for cellular activity. The need for ATP detection in the field of biomedicine is rapidly increasing. Several biosensor-based approaches have been developed as a result of the growing demand for ATP detection.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Department of Physics, City University of Hong Kong, Kowloon 999077, Hong Kong, China.
Amines are one of the most ubiquitous functional groups in molecular junctions; however, the exact regulation of the charge transport through the protonation state of an amine group in the junction backbone remains elusive. We address this question here by designing a diphenylamine molecular backbone and experimentally investigating how protonation of the central amine group affects the charge transport. Our ultraviolet-visible spectroscopy measurements demonstrate the protonation reaction of the diphenylamine compound in the presence of either trifluoroacetic acid or HCl, and we observe a consistent trend of a modestly increased conductance for diphenylamine in the presence of acid, indicating that a protonated amine group in a diphenylamine backbone slightly enhances the electron conduction.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Physical vapor deposition is widely used in the fabrication of organic light-emitting diodes and has the potential to adjust the density and orientation through substrate temperature control, which may lead to enhanced electrical performance. However, it is unclear whether this enhanced property is because of the horizontal molecular orientation or the increased density. The effects of the density and orientation on the electrical properties of a potential electron transport material, (3-dibenzo[c,h]acridin-7-yl)phenyl)diphenylphosphine oxide (TPPO-dibenzacridine), were investigated.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
: The proton-coupled amino acid transporter (PAT1) is an intestinal absorptive solute carrier responsible for the oral bioavailability of some GABA-mimetic drug substances such as vigabatrin and gaboxadol. In the present work, we investigate if non-steroidal anti-inflammatory drug substances (NSAIDs) interact with substrate transport via human (h)PAT1. : The transport of substrates via hPAT1 was investigated in Caco-2 cells using radiolabeled substrate uptake and in oocytes injected with , measuring induced currents using the two-electrode voltage clamp technique.
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