It has been shown that study of immunopathological component in acute pneumonias is of value. Such an approach has demonstrated that in the course of the disease there form immune complexes (IC), which absorb complement and are of importance for the disease pathogenesis, and tissue immune complexes which do not absorb complement. Formation of anticomplement IC in acute pneumonias is in a good agreement with a reduction in blood serum complement level with a concurrent change in these indicators in the lungs. The demonstration of anticomplement IC in patients with acute pneumonia has a prognostic value. The stay at hospital of the patients who demonstrated IC at the very beginning of the disease was 2.5 times longer because of the lack of the process normalization.
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PLoS Pathog
January 2025
Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Function-to-find domain (FIIND)-containing proteins, including NLRP1 and CARD8, are vital components of the inflammasome signaling pathway, critical for the innate immune response. These proteins exist in various forms due to autoproteolysis within the FIIND domain, resulting in full-length (FL), cleaved N-terminal (NT), and cleaved C-terminal (CT) peptides, which form autoinhibitory complexes in the steady state. However, the detailed mechanism remains elusive.
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January 2025
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.
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January 2025
Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
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Vaccines (Basel)
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Institut für Transfusionsmedizin, Universitätsmedizin Greifswald, 17489 Greifswald, Germany.
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State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210092, China.
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