The title compound, C21H15O4P·0.5C4H8O, contains an ordered phosphane oxide in a general position and a tetra-hydro-furan solvent mol-ecule disordered about a twofold axis. All three aldehyde substituents are nearly coplanar with their attached benzene rings, with C-C-C-O torsion angles in the range 1.64 (17)-4.24 (19)°. All three have different conformations with respect to the P=O group, one syn, one anti, and one gauche. Two of the aldehyde substituents form inter-molecular C-H⋯O contacts.
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http://dx.doi.org/10.1107/S1600536813020059 | DOI Listing |
Org Lett
January 2025
Engineering Research Center of Ministry of Education for Fine Chemicals, Shanxi University, Taiyuan 030006, P. R. of China.
Herein a novel and robust methodology to spiroimidazolidinones has been developed under a mild reaction. The reaction of (Z)-2-azido-3-phenylacrylic acids , aldehydes , amines , isocyanides , and isocyanides produced regioselectively spiroimidazolidinones in 71-88% yields via a sequential Ugi 4CR/Pd(0) catalyzed azide-isocyanide coupling/cyclization/rearrangement/hydroxylation reaction. Furthermore, the easily accessible starting materials, high bond-forming efficiency, and broad substituent tolerance make this strategy useful in synthetic and medicinal chemistry.
View Article and Find Full Text PDFJ Org Chem
January 2025
Key Laboratory of Biomass Green Chemical Conversion of Yunnan Provincial Education Department, Yunnan Key La-boratory of Chiral Functional Substance Research and Application, School of Chemistry & Environment, Yunnan Minzu University, Kunming 650504, P. R. China.
We report a base-promoted, metal-free multicomponent tandem reaction, involving a [4 + 1 + 1] cycloaddition process between -substituted nitroarenes, aldehydes, and ammonium salts. Modifying the substituents on the nitroaromatic compounds effectively provides structurally diverse 2-substituted and 4-alkenylquinazolines with good to excellent yields (77%-90% and quinazoline 51 examples) and high tolerance for various inorganic ammonium salts (13 examples, such as NH·HO, NHCl, and NHHF). A new method for constructing 2,4-substituted quinazoline compounds with high selectivity from simple nitrogen source compounds was developed, and the reaction can be scaled up to a gram scale.
View Article and Find Full Text PDFCurr Org Synth
January 2025
Laboratoire de Chimie Organique (LR17ES08), Faculté des Sciences de Sfax, University of Sfax, Route de Soukra Km 3.5, BP 1171, 3000, Sfax, Tunisia.
Aim And Objective: It is well established that 4H-pyran derivatives hold a significant position in synthetic organic chemistry due to their diverse biological and pharmacological properties. This work aims to introduce a novel synthetic pathway for highly functionalized 4H-pyran derivatives, achieved through a 1,4-Michael addition followed by a cascade cyclization. This reaction is catalyzed by LiOH·H2O under ultrasonic irradiation in water, offering an efficient and environmentally friendly approach.
View Article and Find Full Text PDFMolecules
December 2024
Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.
This study examines the influence of ligand design on the structural, optical, and electrical properties of copper-based coordination complexes. Ligands HL and HL were synthesized via the reaction of 5-nitrosalicylaldehyde with 2-hydroxy- or 4-hydroxybenzhydrazide. HL was obtained from the reaction of carbohydrazide and salicylaldehyde, while HL was prepared by condensing 4-methoxysalicylaldehyde with thiocarbohydrazide.
View Article and Find Full Text PDFJ Org Chem
January 2025
Department of Chemistry, IIT Dharwad, Dharwad, Karnataka 580007, India.
The favorable redox properties of ferrocene have led to the extensive development of ferrocene-based systems for several electrochemical applications but have scarcely been explored for electrochromism. Here, we report the synthesis and electrochromic properties of novel π-conjugated ferrocene-dicyanovinylene systems (- and -). Monosubstituted (-) and disubstituted (-) compounds have been developed via Knoevenagel condensation of methyl-dicyanovinyl ferrocenes ( or ) with various aromatic aldehydes.
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