The methyl-substituted imidazolidine ring of the title compound, C24H26N2O2, adopts an envelope conformation with the N atom adjacent to the methyl-ene group as the flap. The meth-yl-ethyl-ene fragment in this ring is disordered over two positions with an occupancy ratio of 0.899 (4):0.101 (4). The hy-droxy-benzyl groups are inclined at 71.57 (15) and 69.97 (19)° to the mean plane of major disorder component of the heterocyclic ring with an inter-planar angle between the two hy-droxy-benzyl groups of 66.00 (5)°. The phenyl substit-uent approaches a nearly perpendicular orientation relative to the mean plane of the imidazolidine ring, making a dihedral angle of 75.60 (12)°. This conformation is stabilized by two intra-molecular O-H⋯N bonds, which generate S(6) ring motifs.
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http://dx.doi.org/10.1107/S1600536813017893 | DOI Listing |
Acta Crystallogr E Crystallogr Commun
October 2024
Laboratory of Organic and Physical Chemistry, Applied Bioorganic Chemistry Team, Faculty of Sciences, Ibnou Zohr University, Agadir, Morocco.
The title mol-ecule, CHBrNO, adopts a cup shaped conformation with the distinctly ruffled imidazolidine ring as the base. In the crystal, weak C-H⋯O hydrogen bonds and C-H⋯π(ring) inter-actions form helical chains of mol-ecules extending along the -axis direction that are linked by additional weak C-H⋯π(ring) inter-actions across inversion centres. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (51.
View Article and Find Full Text PDFJ Nanobiotechnology
December 2024
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.
Polymeric biomaterials have important applications in aiding clinical disease treatment, including drug delivery, bioimaging, and tissue engineering. Currently, conventional tumor chemotherapy faces obstacles such as poor solubility/stability, inability to target, and uncontrolled drug release in clinical trials, for which the emergence of supramolecular material therapeutics combining non-covalent interactions with conventional therapies is a very promising candidate. Due to their molecular recognition abilities with a range of biomolecules, cucurbit[n]uril (CB[n]), a type of macrocyclic receptors with robust backbones, hydrophobic cavities, and carbonyl-binding channels, have garnered a lot of attention.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.
Intestinal bacterial infections have become a significant threat to human health. However, the current typical antibiotic-based therapies not only contribute to drug resistance but also disrupt gut microbiota balance, resulting in additional adverse effects on life activities. There is an urgent need to develop new antibacterial materials that selectively eliminate pathogenic bacteria without disrupting beneficial bacterial communities or promoting drug resistance.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
College of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address:
Carcinoembryonic antigen (CEA) is a common tumor marker used to diagnose diseases. However, the use of molecularly imprinted polymer with whole proteins as templates or antibodies to identify and isolate CEA presents issues such as high prices and difficult removal of templates. Here, due to the specific binding of cucurbit[7]uril (CB[7]) to N-terminal phenylalanine, we prepared a novel oriented epitope molecularly imprinting polymer based on host-guest interaction (hg-MIP) for the identification and separation of CEA.
View Article and Find Full Text PDFOrg Lett
December 2024
Soft Molecular Activation Research Center (SMARC), Chiba Iodine Resource Innovation Center (CIRIC), Synthetic Organic Chemistry, Department of Chemistry, Graduate School of Science, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
A newly developed -9-anthranylmethyl bis(imidazolidine)pyridine (-9-Anth-PyBidine)-Cu(OAc) complex catalyzed asymmetric haloimidation reactions of alkylidenemalononitriles with -bromosuccinimide and -chlorosuccinimide, employing the succinimide moiety directly as a copper-bound nucleophile. The anthranyl substituent showed a gearing effect that produced a well-organized asymmetric sphere involving the -H proton of the imidazolidine ring in the ligand. The gearing effect afforded hydrogen bonding-assisted copper-catalyzed haloimidation reactions with high enantioselectivity.
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