Osteomalacia as inaugural manifestation of Sjögren syndrome.

BMJ Case Rep

Faculty of Medicine of Tunis, Department of Internal Medicine, Charles Nicolle's Hospital, Tunis El Manar, Tunis, Tunisia.

Published: October 2013

Osteomalacia is a relatively common condition, which is frequently underdiagnosed due to lack of clinical suspicion and non-specific symptoms. Osteomalacia can complicate tubulo-interstital nephritis. However, it occurs exceptionally as the first manifestation of Sjögren syndrome with renal involvement. It is a consequence of chronic metabolic acidosis and is associated with distal renal tubular acidosis. We report a 31-year-old woman hospitalised for a 1 year history of muscle weakness and joint and chest wall pains. Skeletal imagery showed Looser's zones in the left femoral neck. Investigations concluded to the diagnosis of primary Sjogren's syndrome.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822150PMC
http://dx.doi.org/10.1136/bcr-2013-201052DOI Listing

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