AI Article Synopsis
- The study investigates the relationship between GLP-2, an intestinal hormone, and inflammation in pediatric patients with ileal Crohn disease (CD).
- Researchers found that while fasting GLP-2 levels remained stable in patients with active CD, postprandial levels decreased, indicating impaired mucosal function and glucose absorption.
- Upon remission from CD, GLP-2 release and nutrient absorption normalized, suggesting potential therapeutic strategies involving GLP-2 and nutritional management in treating CD.
Article Abstract
Unlabelled: BACKGROUND⁄
Objectives: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered by nutrient contact. The authors hypothesized that ileal Crohn disease (CD) affects GLP-2 release.
Methods: With ethics board approval, pediatric patients hospitalized with CD were studied; controls were recruited from local schools. Inclusion criteria were endoscopy-confirmed CD (primarily of the small intestine) with a disease activity index >150. Fasting and postprandial GLP-2 levels and quantitative urinary recovery of orally administered 3-O-methyl-glucose (active transport) and lactulose⁄mannitol (passive) were quantified during the acute and remission phases.
Results: Seven patients (mean [± SD] age 15.3 ± 1.3 years) and 10 controls (10.3 ± 1.6 years) were studied. In patients with active disease, fasting levels of GLP-2 remained stable but postprandial levels were reduced. Patients with active disease exhibited reduced glucose absorption and increased lactulose⁄mannitol recovery; all normalized with disease remission. The change in the lactulose⁄mannitol ratio was due to both reduced lactulose and increased mannitol absorption.
Conclusions: These findings suggest that pediatric patients with acute ileal CD have decreased postprandial GLP-2 release, reduced glucose absorption and increased intestinal permeability. Healing of CD resulted in normalization of postprandial GLP-2 release and mucosal functioning (nutrient absorption and permeability), the latter due to an increase in mucosal surface area. These findings have implications for the use of GLP-2 and feeding strategies as a therapy in CD patients; further studies of the effects of inflammation and the GLP-2 axis are recommended.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805340 | PMC |
| http://dx.doi.org/10.1155/2013/460958 | DOI Listing |
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