AI Article Synopsis
- - The study aimed to assess if osteogenic matrix cell sheets (OMCS) could promote bone formation around grafted tendons in rabbits, which might aid in early tendon-to-bone healing after surgery.
- - Researchers found that OMCS had strong osteogenic properties, demonstrated by high alkaline phosphatase activity and positive bone formation indicators when tested with grafted tendons.
- - Results showed that OMCS significantly increased bone volume and pullout strength at the tendon-bone interface compared to controls, suggesting that OMCS can effectively enhance tendon-to-bone healing post-surgery.
Article Abstract
The objective of this study was to determine whether osteogenic matrix cell sheets (OMCS) could induce bone formation around grafted tendons, thereby enhancing early stage tendon to bone tunnel healing in skeletally mature male Japanese white rabbits. First, the osteogenic potential of rabbit OMCS was evaluated. Then, the OMCS were transplanted into the interface between the grafted tendon and the bone tunnel created at the tibia. Histological assessments and biomechanical tensile testing were performed after 3 weeks. The rabbit OMCS showed high alkaline phosphatase (ALP) activity, positive staining of ALP, and osteogenic potential when transplanted subcutaneously with beta tricalcium phosphate disks. Newly formed bony walls and positive collagen type I staining were seen around the grafted tendon with OMCS transplantation, whereas such bony walls were thinner or less frequent without OMCS transplantation. Micro-computed tomography images showed significantly higher bone volume in the OMCS transplantation group. The pullout strength was significantly higher with OMCS (0.74 ± 0.23 N/mm(2)) than without OMCS (0.58 ± 0.15 N/mm(2)). These results show that OMCS enhance early tendon to bone tunnel healing. This method can be applied to cases requiring early tendon to bone tunnel healing after ligament reconstruction surgery.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784076 | PMC |
| http://dx.doi.org/10.1155/2013/842192 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unlabelled: The increased rate of anterior cruciate ligament (ACL) tears has led to a greater number of revisions. Revision surgery can be performed in one or two stages. Single-stage revision ACL reconstruction (ssRACLR) may be performed when prior tunnels can be re-used or bypassed whereas a two-stage procedure is indicated when bone grafting of dilated tunnels prior to revision is necessary.
View Article and Find Full Text PDFGuide-wire and K-wire readjustment jig for osteotomy and osteosynthesis: An instrument.
J Clin Orthop Trauma
February 2025
Joints and Spine Clinic, Mahavir Nagar, Kandivali West, Mumbai, 400067, India.
Introduction: Numerous orthopaedic procedures including dynamic hip screw plating and various osteotomies require placement of a reference guide pin or K wire to direct bone cuts or for drilling screw holes. Appropriate positioning of these wires is a critical component of surgery. Irrespective of whether one is a seasoned surgeon or an apprentice, these wires often need repositioning and readjustment.
View Article and Find Full Text PDFBone and Nerve Response to Sciatic Compression Neuropathy in a Rabbit Model.
J Orthop Res
January 2025
Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, USA.
Compression neuropathy is a prevalent medical condition, including common types such as carpal tunnel syndrome, cubital tunnel syndrome, sciatica, and many others. While the neurological consequences are well understood, the effects on bone properties and the potential downstream impact on fracture risk remain less clear. This study aimed to assess the influence of compressive neuropathy on bone properties using a rabbit model of sciatic nerve compression.
View Article and Find Full Text PDFRegenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears.
J Transl Med
January 2025
Department of Joint Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Rotator cuff injury (RCI), characterized by shoulder pain and restricted mobility, represents a subset of tendon-bone insertion injuries (TBI). In the majority of cases, surgical reconstruction of the affected tendons or ligaments is required to address the damage. However, numerous clinical failures have underscored the suboptimal outcomes associated with such procedures.
View Article and Find Full Text PDFTunneling nanotubes between bone marrow stromal cells support transmitophagy and resistance to apoptosis in myeloma.
Blood Cancer J
January 2025
Department of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", Bari, Italy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!