Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite).
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http://dx.doi.org/10.3797/scipharm.1212-21 | DOI Listing |
Appl Biochem Biotechnol
January 2025
Department of Plant Sciences, Faculty of Biological Sciences, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
The current research was conducted to synthesize Parietaria alsinifolia-mediated iron oxide nanoparticles (P.A@FeONPs) using the green and eco-friendly protocol. The biosynthesized P.
View Article and Find Full Text PDFAppl Biochem Biotechnol
January 2025
Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq.
The synthesis and characterization of benzo[d]thiazol-2-amine derivatives, which were prepared by reacting benzothiazole with para-aminobenzophenone in ethanol, supplemented with glacial acetic acid. Subsequently, compound (2) was synthesized from compound (1) using NaNO, HPO, and HNO in a water-based solvent, resulting in 2-hydroxy-1-naphthaldehyde. Another derivative, compound (3), was synthesized by reacting compound (1) with vanillin under similar conditions.
View Article and Find Full Text PDFCurr Atheroscler Rep
January 2025
Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Purpose Of Review: Homozygous familial hypercholesterolaemia (HoFH) is characterized by marked elevation of low-density lipoprotein cholesterol (LDLC) and premature atherosclerotic cardiovascular disease. This is a review of novel pharmacological therapies to lower LDLC in patients with HoFH.
Recent Findings: Novel therapies can be broadly divided by whether their efficacy is dependent or independent of residual low-density lipoprotein receptor (LDLR) function.
Plant Cell Rep
January 2025
School of Horticulture and Gardens, Yangzhou University, Yangzhou, 225009, China.
NnNAC100-NnSBEII modules enhance starch content of the rhizome in Nelumbo nucifera Gaertn. Nelumbo nucifera Gaertn. is a popular aquatic vegetable and traditional Chinese medicine whose quality and taste are mainly determined by the starch.
View Article and Find Full Text PDFDalton Trans
January 2025
DICATECh, Politecnico di Bari, Bari, I-70125, Italy.
This systematic study delves into the synthesis and characterization of robust bi-functional aminopropyl-tagged periodic mesoporous organosilica with a high loading of small imidazolium bridges in its framework (PrNH@R-PMO-IL, ∼2 mmol g of IL). The materials proved to be a reliable and enduring support for the immobilization of Ru species, demonstrating strong performance and excellent selectivity in the -bromination of various derivatives of 2-phenylpyridine compounds and other heterocycles, showcasing its effectiveness and robust nature. The synthesized materials were thoroughly characterized to determine their structural properties, such as pore size distribution, loading of organic groups, and surface area, using various analytical techniques.
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