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Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice.
Neurotox Res
December 2024
Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Chronic use of typical antipsychotics can lead to varying motor effects depending on the timing of analysis. Acute treatment typically induces hypokinesia, resembling parkinsonism, while repeated use can result in tardive dyskinesia, a hyperkinetic syndrome marked by involuntary orofacial movements, such as vacuous chewing movements in mice. Tardive dyskinesia is particularly concerning due to its potential irreversibility and associated motor discomfort.
View Article and Find Full Text PDFTakotsubo Syndrome-Induced Cardiogenic Shock in Lung Transplantation: Importance of Early Diagnosis and ECMO Implantation.
Am J Case Rep
November 2024
Department of Anesthesiology, Brussels University Hospital (H.U.B.) Erasme, Brussels, Belgium.
Article Synopsis
- Takotsubo syndrome, a rare condition that mimics a heart attack and leads to temporary heart dysfunction, is often overlooked in lung transplant cases, making awareness crucial for timely diagnosis and treatment.
- A case involving a 54-year-old woman undergoing lung transplantation revealed that she developed severe heart failure during surgery, which was initially misdiagnosed, leading to complications and a prolonged ICU stay.
- This report underscores the need for better monitoring and recognition of takotsubo syndrome in lung transplant patients, as early intervention is vital for improving health outcomes and quality of life.
Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept.
Front Pharmacol
September 2024
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Introduction: Podophyllotoxin (PPT) is a high-content and high-activity compound extracted from the traditional Chinese medicinal plant () which exhibits various biological activities. However, its severe toxicity limits its use. In clinical settings, patients with poisoning often experience adverse reactions when taking large doses in a short period.
View Article and Find Full Text PDFDifferential components of bradykinesia in Parkinson's disease revealed by deep brain stimulation.
J Neurophysiol
September 2024
Division of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.
Bradykinesia is a term describing several manifestations of movement disruption caused by Parkinson's disease (PD), including movement slowing, amplitude reduction, and gradual decrease of speed and amplitude over multiple repetitions of the same movement. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves bradykinesia in patients with PD. We examined the effect of DBS on specific components of bradykinesia when applied at two locations within the STN, using signal processing techniques to identify the time course of amplitude and frequency of repeated hand pronation-supination movements performed by participants with and without PD.
View Article and Find Full Text PDF3-Tesla cardiac magnetic resonance imaging in primary dilated cardiomyopathy.
Afr J Thorac Crit Care Med
April 2024
Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.
Background: Cardiac magnetic resonance imaging (CMR) is an excellent non-invasive imaging tool in the assessment of patients with dilated cardiomyopathy (DCM). Few studies have analysed the findings in primary (idiopathic) DCM.
Objectives: To study the CMR features in primary DCM.
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