AI Article Synopsis
- Genome-wide association studies (GWAS) have found genetic variants that affect cholesterol and triglyceride levels, but the role of environmental factors like smoking is still being explored.
- Researchers analyzed the interactions between smoking and 49 of these variants in a diverse sample of over 41,000 participants from the PAGE study.
- Surprisingly, they did not find significant interactions between the selected SNPs (genetic variants) and smoking, despite the biological reasoning behind such interactions.
Article Abstract
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895337 | PMC |
| http://dx.doi.org/10.1007/s00439-013-1375-3 | DOI Listing |
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