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High plasma adiponectin levels in patients with severe traumatic brain injury. | LitMetric

High plasma adiponectin levels in patients with severe traumatic brain injury.

Clin Chim Acta

Department of Neurosurgery, Shengzhou People's Hospital, 208 Yiyuan Road, Shenzhou 312400, China. Electronic address:

Published: January 2014

AI Article Synopsis

  • The study explores the relationship between plasma adiponectin levels and clinical outcomes in patients with severe traumatic brain injury compared to healthy individuals.
  • Researchers found significantly higher adiponectin levels in brain injury patients, linking it to increased in-hospital mortality and poor outcomes at 6 months.
  • The findings suggest that plasma adiponectin could be a potential biomarker for predicting outcomes after traumatic brain injury, although it didn't enhance predictions made by existing scales like the Glasgow Coma Scale.

Article Abstract

Background: Adiponectin plays an important role in the regulation of tissue inflammation. There is a paucity of data on circulating plasma adiponectin concentrations in human traumatic brain injury. This study is designed to investigate the potential associations between plasma adiponectin levels and clinical outcomes after traumatic brain injury.

Methods: Plasma adiponectin levels of 86 patients with severe traumatic brain injury and 86 healthy subjects were determined. Clinical outcomes included in-hospital mortality, 6-month mortality and 6-month unfavorable outcome (Glasgow Outcome Scale score of 1-3).

Results: Plasma adiponectin levels were significantly higher in patients compared to controls (20.5±5.9 vs. 7.7±2.0μg/ml; P<0.001) and emerged as an independent predictor of in-hospital mortality [odds ratio (OR), 1.318; 95% confidence interval (CI), 1.049-1.629; P=0.008], 6-month mortality (OR, 1.328; 95% CI, 1.082-1.657; P=0.007) and 6-month unfavorable outcome (OR, 1.240; 95% CI, 1.066-1.443; P=0.005) in a multivariate analysis. For predicting these clinical outcomes, areas under receiver operating characteristic curve of plasma adiponectin level were similar to those of Glasgow Coma scale scores (all P>0.05). However, adiponectin did not improve predictive values of Glasgow Coma scale scores (all P>0.05).

Conclusion: Plasma adiponectin level may represent a novel biomarker for predicting clinical outcomes of traumatic brain injury.

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Source
http://dx.doi.org/10.1016/j.cca.2013.09.047DOI Listing

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