Age, plasticity, and homeostasis in childhood brain disorders.

Neurosci Biobehav Rev

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1X8, Canada. Electronic address:

Published: December 2013

It has been widely accepted that the younger the age and/or immaturity of the organism, the greater the brain plasticity, the young age plasticity privilege. This paper examines the relation of a young age to plasticity, reviewing human pediatric brain disorders, as well as selected animal models, human developmental and adult brain disorder studies. As well, we review developmental and childhood acquired disorders that involve a failure of regulatory homeostasis. Our core arguments are as follows:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859812PMC
http://dx.doi.org/10.1016/j.neubiorev.2013.09.010DOI Listing

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