A convenient synthetic route and the characterization of complexes trans-[PtCl2(L)(PPh3)] (L=Et2NH (2), (PhCH2)2NH (3), (HOCH2CH2)2NH) (4) are reported. The antiproliferative activity was evaluated on three human tumor cell lines. The investigation on the mechanism of action highlighted for the most active complex 4 the capacity to affect mitochondrial functions. In particular, both the induction of the mitochondrial permeability transition phenomenon and an aspecific membrane damage occurred, depending on concentration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2013.09.025 | DOI Listing |
Publication Analysis
Top Keywords
synthesis antiproliferative
4
antiproliferative mitochondrial
4
mitochondrial impairment
4
impairment activities
4
activities bis-alkyl-amino
4
bis-alkyl-amino transplatinum
4
transplatinum complexes
4
complexes convenient
4
convenient synthetic
4
synthetic route
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!