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IgE and cardiac disease.
Acta Physiol (Oxf)
February 2025
Department of Physiology, Pharmacology and Toxicology, West Virginia University, Morgantown, West Virginia, USA.
IgE acts primarily via the high affinity IgE receptor (FcεRI) and is central to immediate hypersensitivity reactions (anaphylaxis). However, IgE is also important in the development of chronic hypersensitivity reactions (allergy). In the cardiovascular system, numerous clinical studies have investigated serum IgE levels, mainly in the context of myocardial infarction, and have established a clear association between IgE and ischemic cardiac events.
View Article and Find Full Text PDFFatal Food Anaphylaxis in Children: A Statutory Review in England.
Clin Exp Allergy
January 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Cardiac return assist blanket (CRAB) safely increases central venous pressure.
J Int Med Res
January 2025
Institute for Health Research, the University of Notre Dame Australia, Department of Research, Sir Charles Gairdner Hospital, Nedlands, Australia.
Objective: The cardiac return assist blanket (CRAB) has been designed to increase central venous pressure (CVP) to manage severe hypotension associated with anaphylaxis. This interventional study aimed to identify the relationship between CRAB pressure and CVP. CRAB pressure was also compared with the change in CVP associated with a straight leg raise (SLR), the Trendelenburg position, and 1 L of compound sodium lactate.
View Article and Find Full Text PDFPerioperative anaphylaxis manifesting as cardiac arrest during cardiac surgery.
Allergy Asthma Proc
January 2025
Perioperative anaphylaxis is a serious entity with high morbidity and mortality. Perioperative anaphylaxis can be caused by any of the multitude of medications and substances used in anesthesia and surgery, and the most common causes include neuromuscular blocking agents, antibiotics, antiseptics, latex, and dyes. The differential diagnosis of perioperative anaphylaxis is wide from both an immunologic and a nonimmunologic standpoint.
View Article and Find Full Text PDFComparison of neurological outcomes between out-of-hospital cardiac arrest due to anaphylaxis and cardiac causes: a nationwide population-based observational study.
BMJ Open
December 2024
Department of Emergency Medicine, International University of Health and Welfare Narita Hospital, Narita, Chiba, Japan.
Objective: To compare the neurological outcomes of out-of-hospital cardiac arrest due to anaphylaxis (OHCA-A) and cardiac causes (OHCA-C).
Design: Retrospective observational study.
Setting: Japanese nationwide dataset from 2012 to 2021.
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