AI Article Synopsis
- A study investigated how a GABA synthesis inhibitor (3-MPA) affected amino acids and electrical activity in the striatum and hippocampus of rats.
- Despite inhibiting GABA synthesis, there were unexpected increases in GABA levels (up to 50-fold) along with significant rises in glutamate concentrations during the experiments.
- The findings highlight a complex interaction within neural networks, noting that the effects of disinhibition depend on the experimental model and the activity level of the neural circuits involved.
Article Abstract
In vivo effects of microperfusion of a GABA synthesis inhibitor (3-MPA) into the striatum and hippocampus on amino acid concentrations and electrical neuronal activity were investigated. Paradoxical elevations in GABA in the striatum (5-fold in anesthetized and 50-fold in awake rats) and hippocampus (2-fold in anesthetized and 15-fold in awake rats) were documented under steady-state concentrations of 3-MPA along with expected increases in glutamate (a 15-fold increase and a 250-fold increase in the striatum of anesthetized and awake rats, respectively; a 7-fold increase and a 25-fold increase in the hippocampus of anesthetized and awake rats, respectively). There was no clear epileptiform or seizure activity. Explanations for the paradoxical increase in GABA are offered, and emphasis is placed on the dependency of disinhibition on the model in which its effects are studied as well as on the prevailing level of activation of the probed network.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939839 | PMC |
| http://dx.doi.org/10.1016/j.yebeh.2013.08.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!