To assess, using clinical cases, the potential of a hybrid technique for the treatment of non-small cell lung cancer (NSCLC)-blending volumetric-modulated arc therapy (VMAT) and conformal radiation therapy (CRT) fields, and to consider potential issues with implementation of such a technique. Eight clinical cases already treated with CRT were used for a planning study comparing target coverage and organs at risk (OAR) sparing between CRT and hybrid VMAT (VMATh). Quality assurance (QA) implications of the resultant hybrid plans are discussed. The hybrid technique resulted in superior target conformity or improved sparing of OAR or both. The hybrid technique shows promise, but the QA implications of motion at treatment need careful consideration.
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http://dx.doi.org/10.1016/j.meddos.2013.08.004 | DOI Listing |
Curr Dev Nutr
January 2025
Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, United States.
Background: Existing studies on breast cancer survivors (BCS) have primarily focused on individual aspects of either diet or exercise preferences and barriers. Our study aims to examine BCS' perceptions toward diet and exercise combined. Given the transformative impact of COVID-19, there is a crucial need for insights in the post-pandemic era to address the distinct challenges faced by BCS in maintaining their health and well-being.
View Article and Find Full Text PDFFront Pediatr
January 2025
Henan Provincial Institute of Medical Genetics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Objective: Our study aimed to collect fetuses with recurrent 1q21.1 deletion or duplication syndrome for systematic clinical phenotype analysis to further delineate the intrauterine phenotype features of the two reciprocal syndromes.
Methods: Prenatal samples, including amniotic fluid and chorionic villus samples, were obtained by amniocentesis and chorionic villus sampling at our center, respectively.
Front Neurorobot
January 2025
Software Engineering College, Zhengzhou University of Light Industry, Zhengzhou, China.
Introduction: Tracking the hidden states of dynamic systems is a fundamental task in signal processing. Recursive Kalman Filters (KF) are widely regarded as an efficient solution for linear and Gaussian systems, offering low computational complexity. However, real-world applications often involve non-linear dynamics, making it challenging for traditional Kalman Filters to achieve accurate state estimation.
View Article and Find Full Text PDFNPJ Comput Mater
January 2025
School of Mechanical, Aerospace, and Manufacturing Engineering, University of Connecticut, Storrs, CT USA.
Machine learning has advanced the rapid prediction of inorganic materials properties, yet data scarcity for specific properties and capturing thermodynamic stability remains challenging. We propose a framework utilizing a Graph Neural Network with composition-based and crystal structure-based architectures, combined with a transfer learning scheme. This approach accurately predicts energy-related properties (e.
View Article and Find Full Text PDFPatient Relat Outcome Meas
January 2025
Merck & Co., Inc., Rahway, NJ, USA.
Introduction: The COVID-19 Symptoms Daily Diary (CSDD) is a patient-reported outcome measure designed to assess the severity of core COVID-19 symptoms in clinical trials. The preliminary version of the CSDD was developed based on regulatory guidance and the hallmark COVID-19 symptoms identified by the CDC. This study aimed to evaluate CSDD content validity, to determine whether it is fit for the purpose of supporting efficacy endpoints in clinical trials of treatments for COVID-19.
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