A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 μm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets. Compared to PHEMA sponges that were not functionalized with RGD, the new sponges containing RGD allowed greater invasion by human corneal epithelial cells, by advancing the attachment of cells to the surface of the polymer droplets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.msec.2013.08.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surfactant-free microemulsions (SFMEs) as a template for porous polymer synthesis.
J Colloid Interface Sci
February 2024
Institute of Physical and Theoretical Chemistry, University of Regensburg, 93040 Regensburg, Germany. Electronic address:
Hypothesis: Surfactant-free microemulsions (SFMEs) were recently reported to be an interesting medium for free-radical polymerizations. The aim of this study is to investigate the link between the morphology of PMMA monopolymers as well as PMMA-PHEMA-copolymers with the expected nature of the SFME before polymerization. A surfactant-based microemulsion with nonionic surfactants was investigated as a reference system.
View Article and Find Full Text PDFPortable Nanocomposite System for Wound Healing in Space.
Nanomaterials (Basel)
February 2023
Institute for Polymers, Composites, and Biomaterials CNR-IPCB, Via Paolo Gaifami 18, 95126 Catania, Italy.
It is well known that skin wound healing could be severely impaired in space. In particular, the skin is the tissue at risk of injury, especially during human-crewed space missions. Here, we propose a hybrid system based on the biocompatible poly 2-hydroxyethyl methacrylate (pHEMA) to actively support a nanocontainer filled with the drug.
View Article and Find Full Text PDF[Late Complications After Retinal Surgery Using Hydrogel (MIRAgel®) Sponges].
Klin Monbl Augenheilkd
May 2019
Klinik für Ophthalmologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel.
Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects.
Clin Orthop Relat Res
December 2014
Department of Orthopedics & Physical Rehabilitation, University of Massachusetts Medical School, 55 Lake Ave. North S4-834, Worcester, MA, USA.
Background: Bone grafts simultaneously delivering therapeutic proteins and antibiotics may be valuable in orthopaedic trauma care. Previously, we developed a poly(2-hydroxyethyl methacrylate)-nanocrystalline hydroxyapatite (pHEMA-nHA) synthetic bone graft that, when preabsorbed with 400-ng rhBMP-2/7, facilitated the functional repair of critical-size rat femoral defects. Recently, we showed that pHEMA-nHA effectively retains/releases vancomycin and rhBMP-2 in vitro.
View Article and Find Full Text PDFImproving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: the use of copolymerization as a means to functionalize PHEMA sponges.
Mater Sci Eng C Mater Biol Appl
December 2013
School of Chemistry and Biochemistry, The University of Western Australia (M313), Crawley, WA 6009, Australia.
A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 μm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!