Objective: To evaluate which of 2 measuring units (bivariate contour ellipse area [BCEA] vs Fujii) yields more accurate measurements of fixation stability, obtained using the MP-1 device, in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal injections of ranibizumab, during a 12-month follow-up period.
Design: Small retrospective, noncomparative, interventional case series.
Participants: A total of 25 eyes in 25 patients (13 males, 12 females; mean age 71.72 ± 7.98 years).
Methods: All participants were older than 50 years, diagnosed with active subfoveal choroidal neovascularization, had best corrected visual acuity (BCVA) values above 20/100, and all lesion types were included. All patients underwent a loading phase with 3 consecutive intravitreal injections of 0.05 mg ranibizumab at monthly intervals. Patients were retreated after the third injection if they exhibited a 100-μm increase in macular thickness or evidence of intraretinal and/or subretinal fluid and new subretinal hemorrhage, observed with spectral-domain optical coherence tomography and fluorescein angiography. The data collected included BCVA and mean macular sensitivities, BCEA, and fixation patterns, performed at baseline and at months 4 and 12, using the MP-1 device.
Results: The mean total injection number was 5.92 ± 1.18 (minimum 3, maximum 8). Mean BCVA at baseline was 0.55 ± 0.28 logMAR and increased significantly to 0.50 ± 0.33 logMAR. Mean macular sensitivity at baseline was 7.06 ± 4.59 dB and increased significantly to 8.40 ± 4.82. Mean BCEA was 2.19 ± 1.38 deg(2) and decreased significantly to 1.68 ± 1.43 deg(2). Fixation stability patterns, according to the protocol set out by Fujii, did not change significantly during follow-up.
Conclusions: Compared with Fujii fixation stability patterns, BCEA correlated better with variations in macular sensitivity and BCVA. BCEA can be added to the traditional parameters used to evaluate the efficacy of intravitreal injections in patients with nAMD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcjo.2013.04.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surgical management of single-level thoracolumbar vertebral body segmentation and formation failure causing progressive thoracolumbar myelopathy in three adult large-breed dogs.
Front Vet Sci
January 2025
Lumbry Park Veterinary Specialists, Hampshire, United Kingdom.
Objective: This study aimed to evaluate the medium-term outcome following spinal cord decompression and instrumented fixation of single-level congenital thoracolumbar vertebral malformations, characterized by combined failures of segmentation and formation, causing thoracolumbar myelopathy in three large-breed dogs.
Study Design: This was a retrospective clinical study.
Animals: The animals involved in the study were three large-breed dogs.
Comparative evaluation of ACetic - MEthanol high salt dissociation approach for single-cell transcriptomics of frozen human tissues.
Front Cell Dev Biol
January 2025
Endocrinology Research Centre, Institute of Personalized Medicine, Moscow, Russia.
Current dissociation methods for solid tissues in scRNA-seq studies do not guarantee intact single-cell isolation, especially for sensitive and complex human endocrine tissues. Most studies rely on enzymatic dissociation of fresh samples or nuclei isolation from frozen samples. Dissociating whole intact cells from fresh-frozen samples, commonly collected by biobanks, remains a challenge.
View Article and Find Full Text PDFReshape Iron Nanoparticles Using a Zinc Oxide Nanowire Array for High Efficiency and Stable Electrocatalytic Nitrogen Fixation.
ACS Appl Mater Interfaces
January 2025
Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou 510632, China.
As a type of century-old catalyst, the use of iron-based materials runs through the Haber-Bosch process and electrochemical synthesis of ammonia because of its excellent capability, low cost, and abundant reserves. How to continuously improve its catalytic activity and stability for electrochemical nitrogen fixation has always been a goal pursued by scientific researchers. Herein, we develop a free-standing iron-based catalyst, i.
View Article and Find Full Text PDFInferior outcome of stand-alone short versus long tibial stem in revision total knee arthroplasty. A retrospective comparative study with minimum 2 year follow-up.
SICOT J
January 2025
Department of Orthopedic Surgery and Sport Medicine, Croix-Rousse Hospital, FIFA Medical Center of Excellence, 69004 Lyon, France - Université de Lyon, Université Claude Bernard Lyon 1, IFSTTAR, LBMC UMR_T9406, 69622 Lyon, France.
Introduction: Revision Total Knee Arthroplasty (RTKA) is complex, and induced bone loss might endanger implant fixation and joint stability. Intramedullary stems improve fixation throughout stress redistribution. The current study aims to compare the performance of short tibial stems with long tibial stems, investigating their intermediate-term radiographic and survival outcomes in RTKA.
View Article and Find Full Text PDFUnilateral Lumbo-Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis.
JOR Spine
March 2025
Department of Trauma Surgery, Orthopaedics and Plastic Surgery University Medical Center Göttingen Göttingen Germany.
Background: Unilateral sacral fractures with posterior ring instability represent a prevalent type of posterior pelvic ring fracture. While lumbo-pelvic fixation is recognized as a highly stable method, the sufficiency of unilateral lumbo-pelvic fixation (ULF) for such fractures remains under debate.
Purpose: This study aims to assess the biomechanical stability of ULF compared to traditional bilateral lumbo-pelvic fixation (BLF) and triangular osteosynthesis (TO), incorporating clinical observations, and previous biomechanical data.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!