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The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome: possible explanations. | LitMetric
5-methylcytosine is an important epigenetic modification involved in gene control in vertebrates and many other complex living organisms. Its presence in has been a matter of debate and recent bisulfite sequencing studies of early-stage fly embryos have concluded that the genome of is essentially unmethylated. However, as we outline here, the genome harbors a well-conserved homolog of the TET protein family. The mammalian orthologs TET1/2/3 are known to convert 5-methylcytosine into 5-hydroxymethylcytosine. We discuss several possible explanations for these seemingly contradictory findings. One possibility is that the 2 modified cytosine bases are generated in only at certain developmental stages and in a cell type-specific manner during neurogenesis. Alternatively, Tet and its mammalian homologs may carry out catalytic activity-independent functions, and the possibility that these proteins may oxidize 5-methylcytosine in RNA created by the methyltransferase Dnmt2 should also be strongly considered.
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